NXF5 Antibody, HRP conjugated

Code CSB-PA016223LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NXF5 Polyclonal antibody
Uniprot No.
Target Names
NXF5
Alternative Names
NXF5 antibody; TAPL1 antibody; Nuclear RNA export factor 5 antibody; TAP-like protein 1 antibody; TAPL-1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nuclear RNA export factor 5 protein (1-200AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.
Gene References into Functions
  1. study of an Australian pedigree in which focal segmental glomerulosclerosis co-segregates with progressive heart block; study found 2 mutations NXF5-R113W and ALG13-T141L segregated with disease phenotype; predicted the NXF5 R113W mutation to be deleterious; cellular studies support a role in the stability and localization of the protein suggesting a causative role PMID: 23686279
  2. Mutations of the NXF5 gene is associated with X-linked mental retardation PMID: 12784308
Involvement in disease
A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of mental retardation and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5.
Subcellular Location
Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim.
Protein Families
NXF family
Database Links

HGNC: 8075

OMIM: 300319

KEGG: hsa:55998

STRING: 9606.ENSP00000426978

UniGene: Hs.307077

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