OASL Antibody

Code CSB-PA953473
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA953473(OASL Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA953473(OASL Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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Product Details

Uniprot No.
Target Names
OASL
Alternative Names
2' 5' oligoadenylate synthetase like antibody; 2''-5''-OAS-related protein antibody; 2''-5''-OAS-RP antibody; 2''-5''-oligoadenylate synthase-like protein antibody; 2'-5' oligoadenylate synthetase-like 2 antibody; 2'-5'-oligoadenylate synthetase-like antibody; 59 kDa 2' 5' oligoadenylate synthetase like protein antibody; 59 kDa 2''-5''-oligoadenylate synthase-like protein antibody; 59 kDa 2'-5'-oligoadenylate synthetase-like protein antibody; M1204 antibody; Mmu-OASL antibody; OASL antibody; OASL_HUMAN antibody; Oasl2 antibody; p59 OASL antibody; p59OASL antibody; THYROID HORMONE RECEPTOR INTERACTOR 14 antibody; Thyroid receptor interacting protein 14 antibody; Thyroid receptor-interacting protein 14 antibody; TR-interacting protein 14 antibody; TRIP-14 antibody; TRIP14 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Fusion protein of Human OASL
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Gene References into Functions
  1. These data uncover a promycobacterial role for STING-dependent OASL production during Mycobacterium leprae infection that directs the host immune response toward a niche that permits survival of the pathogen. PMID: 27190175
  2. OASL acts as a cellular antiviral protein and RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth. PMID: 26178980
  3. Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes. PMID: 24328427
  4. these findings show a mechanism by which human OASL contributes to host antiviral responses by enhancing RIG-I activation. PMID: 24931123
  5. we propose that VSV treatment combined with the selective regulation of genes such as STAT1 and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors PMID: 23306614
  6. variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits PMID: 21943158
  7. The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein. PMID: 19203244
  8. The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls. PMID: 20506645
  9. OASLa, a major isoform of OASL induced in human liver, may mediate anti-HCV activity through two different domains. PMID: 20074559
  10. interaction with methyl CpG-binding protein 1 was confirmed in vitro and in vivo and was mapped to the ubiquitin-like domain of p59 OASL PMID: 14728690
  11. Proof that OASL is an antiviral protein that works through a novel mechanism distinct from other OASL proteins in other vertebrate species. PMID: 18931074

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Subcellular Location
[Isoform p56]: Nucleus, nucleolus. Cytoplasm.; [Isoform p30]: Cytoplasm.
Protein Families
2-5A synthase family
Tissue Specificity
Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.
Database Links

HGNC: 8090

OMIM: 603281

KEGG: hsa:8638

STRING: 9606.ENSP00000257570

UniGene: Hs.118633

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