OGDH Antibody

Datasheet

Code	CSB-PA016307LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA016307LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) OGDH Polyclonal antibody

Uniprot No.

Q02218

Target Names

OGDH

Alternative Names

2 oxoglutarate dehydrogenase antibody; 2 oxoglutarate dehydrogenase complex component E1 antibody; 2 oxoglutarate dehydrogenase mitochondrial antibody; 2-oxoglutarate dehydrogenase antibody; 2-oxoglutarate dehydrogenase complex component E1 antibody; AKGDH antibody; Alpha ketoglutarate dehydrogenase antibody; Alpha-ketoglutarate dehydrogenase antibody; E1k antibody; mitochondrial antibody; ODO1_HUMAN antibody; OGDC antibody; OGDC E1 antibody; OGDC-E1 antibody; OGDH antibody; Oxoglutarate (alpha ketoglutarate) dehydrogenase (lipoamide) antibody; Oxoglutarate decarboxylase antibody; Oxoglutarate dehydrogenase (lipoamide) antibody; Oxoglutarate dehydrogenase (succinyl transferring) antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human 2-oxoglutarate dehydrogenase, mitochondrial protein (41-423AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The OGDH Antibody (Product code: CSB-PA016307LA01HU) is Non-conjugated. For OGDH Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA016307LB01HU	OGDH Antibody, HRP conjugated	ELISA
FITC	CSB-PA016307LC01HU	OGDH Antibody, FITC conjugated
Biotin	CSB-PA016307LD01HU	OGDH Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.

Gene References into Functions

PIK3CA mutant cancer cells require PIK3CA but also require the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH). PMID: 28396387
oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS), which when mutated stabilize HIF1alpha in a non-hydroxylated form. PMID: 27923773
Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types PMID: 26936970
ATP consumption is demonstrated in respiration-impaired isolated mice and in situ neuronal mitochondria from transgenic mice with dihydrolipoyl succinyltransferase deficiency. PMID: 23475850
Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium. PMID: 22169199
Differences in oxoglutarate dehydrogenase activity suggest that there is no excess mitochondrial capacity during maximal exercise with a small muscle mass. PMID: 21611730
2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah PMID: 15466852
Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. PMID: 15649899
Association with autosomal recessive DOOR syndrome not found. PMID: 17343268

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Subcellular Location

Mitochondrion matrix. Nucleus.

Protein Families

Alpha-ketoglutarate dehydrogenase family

Database Links

HGNC: 8124

OMIM: 613022

KEGG: hsa:4967

STRING: 9606.ENSP00000222673

UniGene: Hs.488181

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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