OLFM1 Antibody, Biotin conjugated

Code CSB-PA858725LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) OLFM1 Polyclonal antibody
Uniprot No.
Target Names
OLFM1
Alternative Names
AMY antibody; NEUROBLASTOMA PROTEIN antibody; Neuronal olfactomedin-related ER localized protein antibody; Noe1 antibody; NOE1_HUMAN antibody; Noel antibody; Noel1 antibody; Noelin antibody; Noelin1 antibody; OlfA antibody; Olfactomedin 1 antibody; Olfactomedin-1 antibody; Olfm1 antibody; Pancortin 1 antibody; Pancortin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Noelin protein (374-441AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse. May play an important role in regulating the production of neural crest cells by the neural tube. May be required for normal responses to olfactory stimuli.
Gene References into Functions
  1. OLFM1 is a negative regulator of non-canonical NF-kappaB signalling by interacting with and inhibiting NIK. Thus, OLFM1 may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC) patients. PMID: 27555280
  2. human chorionic gonadotropin stimulated miR-212, which down-regulated OLFM1 and CTBP1 expression in fallopian and endometrial epithelial cells to favor spheroid attachment PMID: 26377223
  3. OLF domains from H. sapiens olfactomedin-1 and M. musculus gliomedin were biophysically, biochemically, and structurally characterized. PMID: 26121352
  4. Down-regulation of OLFM1 in fallopian tube epithelial cells enhances spheroid attachment to fallopian tube. PMID: 25999259
  5. Wnt activation suppresses Olfm-1 expression, and this may predispose a favorable microenvironment of the retained embryo in the Fallopian tube, leading to ectopic pregnancy in humans PMID: 21968811

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Subcellular Location
Secreted. Cell junction, synapse. Endoplasmic reticulum. Cell projection, axon. Perikaryon.
Database Links

HGNC: 17187

OMIM: 605366

KEGG: hsa:10439

STRING: 9606.ENSP00000252854

UniGene: Hs.522484

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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