OLFM2 Antibody

Datasheet

Code	CSB-PA016321GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O95897

Target Names

OLFM2

Alternative Names

Neuronal olfactomedin related ER localized protein 2 antibody; NOE2 antibody; NOE2_HUMAN antibody; Noelin 2 antibody; Noelin-2 antibody; NOELIN2 antibody; NOELIN2 V1 antibody; Olfactomedin 2 antibody; Olfactomedin-2 antibody; OlfC antibody; Olfm2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human OLFM2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling.

Gene References into Functions

plasma OLFM2 is a potential biomarker for restenosis and may be a novel target for the treatment of restenosis. PMID: 29553861
Our study indicates that OLFM2 is likely to be important in mammalian eye development and disease and should be considered as a gene for human ocular anomalies. PMID: 27844144
Olfm2 physically interacts with serum response factor (SRF) without affecting the SRF-myocardin interaction. PMID: 25298399
The Arg144Gln mutation in OLFM2 is a possible disease-causing mutation in Japanese patients with OAG. Common polymorphisms in OLFM2 and OPTN may interactively contribute to the development of OAG, indicating a polygenic etiology. PMID: 17122126

Subcellular Location

Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm.

Tissue Specificity

Expressed in aortic smooth muscle (at protein level). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup.

Database Links

HGNC: 17189

OMIM: 617492

KEGG: hsa:93145

STRING: 9606.ENSP00000264833

UniGene: Hs.169743

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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