OPLAH Antibody

Code CSB-PA016350GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
OPLAH
Alternative Names
5 Opase antibody; 5 oxo L prolinase antibody; 5 oxoprolinase (ATP hydrolysing) antibody; 5 oxoprolinase antibody; 5-OPase antibody; 5-oxo-L-prolinase antibody; 5-oxoprolinase antibody; DKFZp434H244 antibody; OPLA antibody; OPLA_HUMAN antibody; oplah antibody; OPLAHD antibody; Pyroglutamase antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human OPLAH
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Gene References into Functions
  1. An autosomal recessive mode of inheritance for 5-oxoprolinase deficiency is further supported by the identification of a single mutation in all 9/14 parent sample sets investigated (except for the father of one patient whose result suggests homozygosity), and the absence of 5-oxoprolinuria in all tested heterozygotes PMID: 27477828
  2. In this study, clinical, biochemical, and genetic aspects of five Chinese 5-oxoprolinuria patients with OPLAH or GSS gene mutations were investigated. PMID: 25851806
  3. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase PMID: 20413906
Involvement in disease
5-oxoprolinase deficiency (OPLAHD)
Protein Families
Oxoprolinase family
Database Links

HGNC: 8149

OMIM: 260005

KEGG: hsa:26873

UniGene: Hs.305882

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