OPRL1 Antibody, FITC conjugated

Datasheet
Code CSB-PA016360LC01HU
Size US$299
Uniprot No. P41146
Protocols ELISA Protocol
Immunogen Recombinant Human Nociceptin receptor protein (323-370AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor), OPRL1, OOR ORL1
Immunogen Species Homo sapiens (Human)
Research Area Neuroscience
Target Names OPRL1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Subcellular Location Cell membrane, Multi-pass membrane protein, Cytoplasmic vesicle
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Detected in blood leukocytes.
Database Links

HGNC: 8155

OMIM: 602548

KEGG: hsa:4987

STRING: 9606.ENSP00000336764

UniGene: Hs.2859

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