Recombinant Human Nociceptin receptor(OPRL1)

Code CSB-CF016360HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P41146
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Gene Names OPRL1
Protein Names Recommended name: Nociceptin receptor Alternative name(s): Kappa-type 3 opioid receptor Short name= KOR-3 Orphanin FQ receptor
Expression Region 1-370
Tag Info N-terminal 10xHis-tagged
Protein Description Full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Subcellular Location Cell membrane, Multi-pass membrane protein, Cytoplasmic vesicle
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Detected in blood leukocytes.
Database Links

HGNC: 8155

OMIM: 602548

KEGG: hsa:4987

STRING: 9606.ENSP00000336764

UniGene: Hs.2859

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