ORMDL1 Antibody

Code CSB-PA868379LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA868379LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA868379LA01HU at dilution of 1:100

  • Immunofluorescent analysis of 293T cells using CSB-PA868379LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ORMDL1 Polyclonal antibody
Uniprot No.
Target Names
ORMDL1
Alternative Names
ORMDL1; HSPC202; ORM1-like protein 1; Adoplin-1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human ORM1-like protein 1 protein (48-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ORMDL1 Antibody (Product code: CSB-PA868379LA01HU) is Non-conjugated. For ORMDL1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA868379LB01HU ORMDL1 Antibody, HRP conjugated ELISA
FITC CSB-PA868379LC01HU ORMDL1 Antibody, FITC conjugated
Biotin CSB-PA868379LD01HU ORMDL1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Negative regulator of sphingolipid synthesis.
Gene References into Functions
  1. ORMDL1 downregulation modestly increased levels of sphingosine, S1P, and ceramide in HepG2 cells. PMID: 27313060
  2. Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells. PMID: 25395622
  3. ORMDL1, ORMDL2 and ORMDL3 mediate the feedback response in ceramide biosynthesis. PMID: 23066021
  4. Adoplin-1/ORMDL-1 displays reduced expression in association with presenilin mutations; Adoplin-1 & two highly homologous genes (adoplin-2, -3) are a gene family that encodes transmembrane proteins that may play roles in gamma-secretase complex maturation PMID: 17928364
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
ORM family
Tissue Specificity
Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. Expressed at intermediate level in pancreas, placenta and brain but low in skele
Database Links

HGNC: 16036

OMIM: 610073

KEGG: hsa:94101

STRING: 9606.ENSP00000326869

UniGene: Hs.700632

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