OSBPL2 Antibody

1. point at a novel function of ORP2 as a lipid-sensing regulator of the actin cytoskeleton, with impacts on hepatocellular migration, adhesion, and proliferation PMID: 29092904
2. this study identifies ORP2 as a new regulatory nexus of Akt signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation. PMID: 29947926
3. a novel role for ORP2 in regulating steroidogenic capacity and cholesterol homeostasis in the adrenal cortex PMID: 26992564
4. This study and the recent description of another frameshift mutation in a Chinese ADNSHL family identify OSBPL2 as a novel gene for progressive deafness. PMID: 25759012
5. Results identified frameshift and missense mutation in OSBPL2 gene in familial and sporadic case of deafness suggesting OSBPL2 as a novel candidate gene for autosomal dominant nonsyndromic hearing loss . PMID: 25077649
6. ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking. PMID: 11861666
7. Results identify ORP2 as a sterol receptor present on LD and provide evidence for its role in the regulation of neutral lipid metabolism, possibly as a factor that integrates the cellular metabolism of triglycerides with that of cholesterol. PMID: 19224871

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HGNC: 15761

OMIM: 606731

KEGG: hsa:9885

STRING: 9606.ENSP00000316649

UniGene: Hs.473254