OSR1 Antibody

1. Kir2.1 and Kir2.3, are activated by OSR1 through a motif variant, R-x-F-x-V/I. PMID: 29581290
2. Odd-skipped related 1 (OSR1) downregulated the activity of the Wnt signaling pathway by suppressing the expression of sex-determining region Y-box 9 (SOX9) and beta-catenin. PMID: 29660200
3. OSR1 was downregulated in RCC cells by promoter methylation. OSR1 can function as a tumor suppressor via inhibition of invasion and proliferation in RCC cells, possibly via upregulating tumor suppressor genes and downregulating oncogenes. PMID: 28404905
4. OSR1 was sequenced in 186 children with primary vesicoureteric reflux, and 17 have single nucleotide polymorphisms PMID: 28724605
5. In summary, our study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 in congenital heart disease ontogeny. PMID: 26744331
6. The findings of the present study showed, for the first time, the role of the OSR1 rs12329305 polymorphism in the development of congenital malformations in cases of stillborn/neonatal death. PMID: 25164089
7. OSR1 acts as a functional tumour suppressor in gastric cancer PMID: 24931004
8. OSR1 is expressed in human mesenchymal stem cells, the blastemal component of Wilms tumors and CD24+/CD133+ progenitor cells isolated from the mature kidney. PMID: 21821672
9. first report on molecular cloning and characterization of human OSR1 PMID: 12119563

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HGNC: 8111

OMIM: 608891

KEGG: hsa:130497

STRING: 9606.ENSP00000272223

UniGene: Hs.123933