OTUD5 Antibody, Biotin conjugated

Code CSB-PA850298LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) OTUD5 Polyclonal antibody
Uniprot No.
Target Names
OTUD5
Alternative Names
Deubiquinating enzyme A antibody; Deubiquitinating enzyme A antibody; DKFZp761A052 antibody; DUBA antibody; MGC104871 antibody; OTTHUMP00000025821 antibody; OTU domain containing 5 antibody; OTU domain containing protein 5 antibody; OTU domain-containing protein 5 antibody; OTUD 5 antibody; otud5 antibody; OTUD5_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human OTU domain-containing protein 5 protein (51-183AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).
Gene References into Functions
  1. Findings have uncovered an apoptotic signaling cascade linking PDCD5, OTUD5, and p53 during genotoxic stress responses. PMID: 25499082
  2. OTUD5 is required for the stabilization and the activation of a p53 response PMID: 24143256
  3. Here the authors show that phosphorylation of the human deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both necessary and sufficient to activate the enzyme. PMID: 22245969
  4. data identify DUBA as a negative regulator of innate immune responses PMID: 17991829
Protein Families
Peptidase C85 family
Tissue Specificity
Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.
Database Links

HGNC: 25402

OMIM: 300713

KEGG: hsa:55593

STRING: 9606.ENSP00000156084

UniGene: Hs.496098

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