OTUD5 Antibody, HRP conjugated

Datasheet

Code	CSB-PA850298LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) OTUD5 Polyclonal antibody

Uniprot No.

Q96G74

Target Names

OTUD5

Alternative Names

Deubiquinating enzyme A antibody; Deubiquitinating enzyme A antibody; DKFZp761A052 antibody; DUBA antibody; MGC104871 antibody; OTTHUMP00000025821 antibody; OTU domain containing 5 antibody; OTU domain containing protein 5 antibody; OTU domain-containing protein 5 antibody; OTUD 5 antibody; otud5 antibody; OTUD5_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human OTU domain-containing protein 5 protein (51-183AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).

Gene References into Functions

Findings have uncovered an apoptotic signaling cascade linking PDCD5, OTUD5, and p53 during genotoxic stress responses. PMID: 25499082
OTUD5 is required for the stabilization and the activation of a p53 response PMID: 24143256
Here the authors show that phosphorylation of the human deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both necessary and sufficient to activate the enzyme. PMID: 22245969
data identify DUBA as a negative regulator of innate immune responses PMID: 17991829

Protein Families

Peptidase C85 family

Tissue Specificity

Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.

Database Links

HGNC: 25402

OMIM: 300713

KEGG: hsa:55593

STRING: 9606.ENSP00000156084

UniGene: Hs.496098

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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