OXT Antibody, Biotin conjugated

Code CSB-PA017315LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) OXT Polyclonal antibody
Uniprot No. P01178
Target Names OXT
Alternative Names OXT antibody; OT antibody; Oxytocin-neurophysin 1 antibody; OT-NPI) [Cleaved into: Oxytocin antibody; Ocytocin); Neurophysin 1] antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Oxytocin-neurophysin 1 protein (27-123AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Neurophysin 1 specifically binds oxytocin.; FUNCTION
Gene References into Functions
  1. The results suggest that there is an age-dependent association between visual attention for social cues and oxytocin (OT) levels in infants and children, and that the development of visual attention to the eyes as social cues is associated with both OXTR polymorphisms and OT levels. PMID: 28566712
  2. Although some SNPs were associated at an alpha level of .05 with breastfeeding, they did not survive multiple testing correction. Authors conclude that SNPs within or nearby OXT and OXTR are unlikely to have large effects on breastfeeding behavior. PMID: 29412506
  3. Oxytocin gene polymorphisms and parenting G x E interaction on social anxiety levels in adolescents. PMID: 28606214
  4. serum oxytocin levels were higher among women than men and were negatively associated with strength of belief in life after death PMID: 26898770
  5. A significant moderating effect of OXT genotype (rs2740210) on the relationship between social support and psychiatric distress was detected PMID: 29040351
  6. findings suggested more significant plasma oxytocin dysregulation in the patients in the bipolar II disorder group than in the major depressive disorder patients and controls, both before and after treatment PMID: 28865715
  7. Oxytocin level did not vary significantly between healthy controls, healthy controls with a history of sexual abuse, and psychogenic non-epileptic seizure patients with a history of sexual abuse. PMID: 28927333
  8. These results suggest that OXT and OXTR are controlled mainly by E2 in the placenta via ESR1 and thus may play physiological functions in the human placenta during the late stage of pregnancy. PMID: 28694300
  9. Study found a higher expression of paraventricular nucleus OXT in the mood disorder patients than in the control subjects, and observed a clear co-localization of androgen receptor in OXT-expressing neurons, both in the cytoplasm and in the nucleus. In addition, a significant decrease in OXT-mRNA levels was observed after pre-incubation of the SK-N-SH cells with testosterone. PMID: 28447621
  10. Serum and prostatic oxytocin levels are increased in the PCa subjects. Serum oxytocin level may be a biomarker for PCa in the future. Oxytocin increases PCa growth and APPL1 expression. PMID: 28415720
  11. Obese children had significantly higher irisin and lower oxytocin levels than the healthy controls. PMID: 28077341
  12. study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population PMID: 27818356
  13. OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density. PMID: 28586943
  14. epigenetic modification of OXT is linked to several overt measures of sociability PMID: 27325757
  15. Hormonal changes in estradiol, progesterone, or oxytocin do not predict differences in the pain perception of women in the peripartum or postpartum period. PMID: 27028773
  16. Oxytocin prevents cartilage matrix destruction via regulating MMP1 and MMP13. PMID: 28238786
  17. Low oxytocin expression is associated with diabetic metabolic syndrome. PMID: 27578619
  18. Oxytocin levels were lower in autistic patients compared to controls. PMID: 26739971
  19. Children with Prader-Willi syndrome have elevated plasma oxytocin levels. PMID: 26615966
  20. This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor. PMID: 22294460
  21. Oxytocin serum levels with Attention Deficit Hyperactivity Disorder were significantly decreased compared with controls. PMID: 26168929
  22. reviews the role of OT in the control mechanisms of sexual behavior. PMID: 25088178
  23. Oxytocin activates NF-kappaB-mediated inflammatory pathways in human gestational tissues in normal parturition. PMID: 25451977
  24. Report for the first time of a significant genetic association of OXT and AVP with schizophrenia PMID: 21899794
  25. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38 PMID: 24635660
  26. findings suggest that experiences of childhood emotional maltreatment may alter salivary oxytocin levels, which in turn are related to more positive perceptions of infant stimuli with positive emotion PMID: 24768649
  27. Patients with poor outcome after aneurysmal subarachnoid hemorrhage have lower AVP and OXT levels in cerebrospinal fluid. PMID: 24412107
  28. dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children. PMID: 24086383
  29. OXT rs2740210 interacted with early life adversity to predict variation in breastfeeding duration and postpartum depression. PMID: 23941164
  30. Women with low OT may not effectively interpret and utilize available support resources, which may be associated with sleep disturbances PMID: 23799864
  31. Oxytocin plays an important role in modulation of social bonding processes and stress regulation, and may be crucially involved in the promotion of mental health. Review. PMID: 23856187
  32. Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical myoma pseudocapsules exhibit substantial nerve fibers expressing OXT; uterine fundal myoma pseudocapsules exhibit few nerve fibers expressing OXT. PMID: 23937196
  33. Data suggest that that OXT enhances pro-social behavior by influencing complex brain networks involved in self-referential processing and affectionate touch, most prominently in individuals with supportive family experiences in childhood. PMID: 23453164
  34. findings suggest that oxytocin might not promote human bond formation in ways analogous to prairie voles - that is, by inducing a partner preference effect PMID: 22920910
  35. OT increases covert attention to happy faces, thereby supporting the hypothesis that OT modulates early attentional processes that might promote prosocial behavior in healthy men. PMID: 23146328
  36. In couples, relationship quality had a small, marginally significant inverse association with plasma oxytocin levels. PMID: 22543270
  37. polymorphisms in OXT associate with both infant-directed vocalizing and maternal instrumental care. PMID: 23637833
  38. Results indicate that oxytocin, beyond its role in social bonding, regulates non-homeostatic, reward-related energy intake, hypothalamic-pituitary-adrenal axis activity, and the glucoregulatory response to food intake in humans. PMID: 23835346
  39. OT inhibits neuroadaptation to and withdrawal from alcohol. PMID: 23025690
  40. OT is a regulator of the PI3K/Akt/mTORC1 pathway in Caco2BB cells and may modulate translation in gut cells. PMID: 23410756
  41. kisspeptin-10 transiently excites oxytocin neurons in late pregnancy and during lactation, suggesting that a central kisspeptin excitation of oxytocin neurons emerges at the end of pregnancy PMID: 23550008
  42. Women who perceived low cognitive social capital showed higher oxytocin levels, while structural social capital showed inverse-U shape association with oxytocin. No association between oxytocin and social capital was found among men. PMID: 23284856
  43. oxytocin and argipressin have been referred to as "social" neuropeptides as they have a highly conserved role as mediators of complex social cognition and interaction in both animals and humans PMID: 23589638
  44. The study links defense-motivated competition to oxytocin, a hypothalamic neuropeptide involved in reproduction and social bonding. PMID: 23144787
  45. Results show low plasma oxytocin levels in patients with generalized social anxiety disorder compared to controls during a prosocial laboratory task paradigm. PMID: 22807189
  46. Data suggest that nocturnal oxytocin secretion is low in amenorrheic athletes compared with nonathletes and is associated with site-dependent microarchitectural parameters of bone (tibia [weight-bearing]; radius [non-weight-bearing]). PMID: 23258269
  47. [review] The OT system functions as an important element within a complex, developmentally sensitive biobehavioral system. PMID: 21984889
  48. Data suggest that plasma oxytocin is lower in subjects with uncontrolled type 2 diabetes along with psychoticism, somatization, or obsessionality as compared with subjects with controlled type 2 diabetes. PMID: 22997507
  49. first evidence or relationship between plasma oxytocin level and expression of SERT (serotonin transporter) on platelet membranes PMID: 22297159
  50. Oxytocin may be involved in the pathophysiology of anorexia. PMID: 22872688
  51. variability within the oxytocin gene appear to explain interindividual differences in dopaminergic responses to stress PMID: 22418012
  52. Reduced plasma oxytocin and both oxytocin receptor and CD38 risk alleles were related to less parental touch PMID: 22336563
  53. Arginine vasopressin and oxytocin are social hormones and mediate affiliative behaviors in mammals and as recently demonstrated, also in humans--REVIEW PMID: 22245314
  54. Studies across multiple attachments throughout life are presented and demonstrate that the extended oxytocin system provides the neurohormonal substrate for parental, romantic, and filial attachment in humans--REVIEW PMID: 22285934
  55. These findings link differences in individual temperament in new mothers with the peripheral oxytocin response PMID: 22306668
  56. The author reviews evidence that hypothalamic release (or infusion) of the neuropeptide oxytocin modulates the regulation of cooperation and conflict among humans--REVIEW PMID: 22227278
  57. Plasma oxytocin concentration in mid-pregnancy predicts post-partum depression symptoms characterized in this prospective study. PMID: 21562482
  58. These results contribute to the evidence that early life adverse experience is negatively associated with OT system activity in adulthood, and offer further insight into mediator and moderator effects on this link. PMID: 21682649
  59. [review] OT and arginine vasopressin play parallel roles in modulating the recognition and avoidance of socially relevant pathogen threats in both humans and rodents. PMID: 21960250
  60. Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes. PMID: 22069312
  61. Overnight secretion of oxytocin in women with anorexia nervosa is decreased compared with healthy women; low oxytocin levels are associated with decreased bone mineral density and body fat and may contribute to anorexia nervosa-induced bone loss. PMID: 21903023
  62. Oxytocin plays an important role in multiple social behaviors, demonstrated in a model comprising oxytocinergic signaling in the amygdala that results in impaired emotional salience processing with consequent social cognitive deficits. PMID: 20308198
  63. analysis of oxytocin immunoreactivity in the corpus cavernosum of patients with erectile dysfunction PMID: 21832819
  64. These results suggest that CD38 plays a general role in oxytocin secretion PMID: 21893160
  65. Significant differences in the content of OT and expression of OTR between fertile and infertile men suggested an association of OT with male infertility. PMID: 21090345
  66. there is a local feed-forward loop in bone marrow through which the OT so produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action. PMID: 21741363
  67. This review discusses the function of oxytocin (OT) as a homeostatic inhibitor of consumption, capable of mitigating multiple aspects of ingestive behavior and energy metabolism. PMID: 20595062
  68. The exocytosis of oxytocin, expressed in neurons of the hypothalamus, is negatively regulated by synaptotagmin 4. PMID: 21315262
  69. Significantly different oxytocin baseline concentrations and oxytocin receptor expressions between fertile and infertile men strongly suggest that oxytocin/oxytocin receptor system is likely to be linked with male infertility PMID: 20711752
  70. No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. PMID: 20547007
  71. Immunohistochemical experimentation with oxytocin in this review shows that during cancer progression, atrial natriuretic peptide is reduced, but oxytocin (OT) is not, and OT could be used as a novel marker to predict breast cancer progression. [review] PMID: 21073007
  72. Prolactin was related to father-infant coordinated exploratory play whereas oxytocin was associated with father-infant affect synchrony in the social context. PMID: 20399783
  73. The findings of this study suggested a nominal association of schizophrenia with two variants in the 5' region of the oxytocin gene (rs4813625 and rs3761248). PMID: 20547038
  74. These data confirm and extend prior evidence implicating oxytocin and vasopressin in couples' positive and negative communication behaviors, and also provide further evidence of their role in an important health outcome, wound healing. PMID: 20144509
  75. The rs2740204 variant in the OXT gene was significantly associated with treatment response (after 1000 permutations p=0.042) and nominally associated with negative symptoms in the sample of this study. PMID: 20196918
  76. First demonstration that intranasal oxytocin can facilitate amygdala-dependent, socially reinforced learning and emotional empathy in men. PMID: 20371820
  77. Hyperphagic obesity in single-minded homolog 1 (Sim1)-deficient mice may be attributable to transgenic changes in the leptin-melanocortin-oxytocin pathway. PMID: 20220015
  78. Gene expression of vasopressin and oxytocin was significant increased in the hypothalamo-neurohypophysial system of patients with chronic heart failure. PMID: 19672816
  79. polymorphism in the promoter region of the OXT gene is most common in subjects with lactase non-persistence. PMID: 19943975
  80. oxytocin decreases IL-6 production and may affect bone metabolism in humans PMID: 12126740
  81. Plasma oxytocin levels were not reliably altered by positive or negative emotion induction. PMID: 12475731
  82. oxytocin has a role in the physiological processes of LH regulation. PMID: 12832367
  83. New function of estrogens in the male: regulation of OT responsiveness in epididymis. PMID: 12834028
  84. Paracrine oxytocin production stimulated by estrogen may be important in activating the uterus at term. PMID: 12843193
  85. The inhibitory effect of oxytocin is mediated by activation of the cAMP-protein kinase A pathway, a nonconventional oxytocin signalling pathway, whereas the mitogenic effect is coupled to the increase of intracellular [Ca(2+)] and tyrosine phosphorylation PMID: 15089975
  86. OT and OT-receptor mRNAs are expressed throughout the GI tract PMID: 15093695
  87. Data show that oxytocin is expressed in the myenteric and submucous ganglia and nerve fibres along the entire human GI tract. PMID: 16678285
  88. These data indicate that oxytocin contributes to cell motility and growth in human dermal microvascular endothelial cells and tumor-associated endothelial cells purified from human breast carcinomas. PMID: 16778082
  89. Data suggest that oxytocin improves the ability to infer the mental state of others from social cues of the eye region. Oxytocin might play a role in autism spectrum disorder, characterized by severe social impairment. PMID: 17137561
  90. increase in OXT mRNA in melancholically depressed patients could be related to specific symptoms of depression PMID: 17252002
  91. Changes in prostatic concentrations of oxytocin (OT) that occur with aging and malignant disease may act to facilitate cell proliferation. Localization of oxytocin receptor within the plasma membrane modulates OT's proliferative response in the prostate. PMID: 17492653
  92. Implications for understanding and researching the role of oxytocin in women's attachment, affiliation and aggression are discussed--REVIEW PMID: 17931766
  93. Both 5-alpha-reductase I and II are expressed in normal human prostate stromal and epithelial cells. Only 5-alpha-reductase isoenzymes of prostate epithelium are modulated by oxytocin. PMID: 18008328
  94. Opposite effects of OXT on proliferation of osteosarcoma cell lines are reported. PMID: 18384894
  95. No OXT coding variants are found, but two novel low-frequency single nucleotide polymorphisms are discovered in the 5' flanking regions in African populations, one of which lies in the most highly conserved segment outside the exons. PMID: 18566739
  96. reduced oxytocinergic function may be one of multiple biological factors contributing to the greater sensitivity to experimental ischemic pain, and to the greater burden of some types of clinical pain experienced by African Americans compared with Whites. PMID: 18568974
  97. During conditions of extreme physical stress such as prolonged endurance running, oxytocin may assist its better known companion hormones (arginine vasopressin and atrial natriuretic peptide) in the regulation of fluid balance. PMID: 18794210
  98. The fact that oxytocin decreases both superoxide production and release of a proinflammatory cytokine from these cells suggests a potentially larger role for oxytocin in the attenuation of disease. PMID: 18940936
  99. Depressed women had more variability in pulsatile oxytocin release during 2 test tasks, & higher oxytocin levels during the 1-hour affiliation-focused imagery session which were also associated with more depression, anxiety, & interpersonal dysfunction. PMID: 19005082
  100. oxytocin deserves to be examined as a candidate that causes the sexually dimorphic aspect of human social reciprocity, social brain development and the pathogenesis of autism spectrum disorder PMID: 19335381

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Subcellular Location Secreted
Protein Families Vasopressin/oxytocin family
Database Links

HGNC: 8528

OMIM: 167050

KEGG: hsa:5020

STRING: 9606.ENSP00000217386

UniGene: Hs.113216

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