PACS2 Antibody, HRP conjugated

1. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis. PMID: 29656858
2. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
3. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
4. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells PMID: 24633224
5. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
6. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2. PMID: 22645134
7. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
8. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis PMID: 15692567
9. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system PMID: 18296443
10. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane PMID: 18417615
11. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action. PMID: 19481529

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HGNC: 23794

OMIM: 610423

KEGG: hsa:23241

STRING: 9606.ENSP00000393559

UniGene: Hs.525626