PACSIN3 Antibody, Biotin conjugated

Code CSB-PA892456LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PACSIN3 Polyclonal antibody
Uniprot No.
Target Names
PACSIN3
Alternative Names
Endophilin 1 antibody; Endophilin I antibody; FLJ17861 antibody; OTTHUMP00000234262 antibody; OTTHUMP00000234263 antibody; OTTHUMP00000234264 antibody; PACN3_HUMAN antibody; Pacsin3 antibody; Protein kinase C and casein kinase substrate in neurons 3 antibody; Protein kinase C and casein kinase substrate in neurons protein 3 antibody; SDPIII antibody; SH3 domain containing protein 6511 antibody; SH3 domain-containing protein 6511 antibody; syndapin III antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 3 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
Gene References into Functions
  1. Show that in neuroendocrine chromaffin cells fusion pore expansion and catecholamine release are limited specifically by mutation of syndapin 3. PMID: 24500282
  2. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules PMID: 22573331
  3. PACSIN3 has a novel function as an up-regulator in the signaling of proHB-EGF shedding induced by TPA and angiotensin II PMID: 12952982
  4. PACSIN 3 acts as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner. PMID: 18174177
Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
PACSIN family
Tissue Specificity
Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.
Database Links

HGNC: 8572

OMIM: 606513

KEGG: hsa:29763

STRING: 9606.ENSP00000298838

UniGene: Hs.334639

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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