PAIP1 Antibody

Code CSB-PA017400GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PAIP1
Alternative Names
MGC12360 antibody; OTTHUMP00000221601 antibody; OTTMUSP00000026880 antibody; PABC1 interacting protein 1 antibody; PABP interacting protein 1 antibody; PABP-interacting protein 1 antibody; PAIP 1 antibody; PAIP-1 antibody; Paip1 antibody; PAIP1_HUMAN antibody; Poly(A) binding protein interacting protein 1 antibody; Poly(A)-binding protein-interacting protein 1 antibody; Polyadenylate binding protein interacting protein 1 antibody; Polyadenylate-binding protein-interacting protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PAIP1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.; (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.
Gene References into Functions
  1. Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes. PMID: 29358694
  2. Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation. PMID: 25266661
  3. The Paip1-eIF3 interaction is impaired by the mTORC1 inhibitors. PMID: 24396066
  4. the crystal structure of the middle domain of Paip1 isoform 2 (Paip1M) as determined by single-wavelength anomalous dispersion phasing is reported. PMID: 21539810
  5. Paip1 is translational activator in 5' cap-dependent translation by interacting with PABP & initiation factors eIF4A & eIF3. Crystallization & preliminary diffraction analysis of middle domain of Paip1 gives crystals that diffract to resolution of 2.2 A. PMID: 19851022
  6. Paip1 interacts with poly(A) binding protein through two independent binding motifs. PMID: 11997512
  7. eIF3-Paip1 stabilizes the interaction between PABP and eIF4G, which brings about the circularization of the mRNA. PMID: 18725400

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Subcellular Location
Cytoplasm.
Database Links

HGNC: 16945

OMIM: 605184

KEGG: hsa:10605

STRING: 9606.ENSP00000302768

UniGene: Hs.482038

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