PANK1 Antibody

Datasheet

Code	CSB-PA017421LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017421LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA017421LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PANK1 Polyclonal antibody

Uniprot No.

Q8TE04

Target Names

PANK1

Alternative Names

coaA antibody; hPanK antibody; hPanK1 antibody; PANK antibody; PANK1 antibody; PANK1_HUMAN antibody; PANK1a antibody; PANK1b antibody; PanK1beta antibody; Pantothenate kinase 1 antibody; Pantothenate kinase antibody; Pantothenic acid kinase 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pantothenate kinase 1 protein (462-582AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PANK1 Antibody (Product code: CSB-PA017421LA01HU) is Non-conjugated. For PANK1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA017421LB01HU	PANK1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017421LC01HU	PANK1 Antibody, FITC conjugated
Biotin	CSB-PA017421LD01HU	PANK1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.

Gene References into Functions

p53 plays an important role in regulating energy homeostasis through transcriptional control of PANK1. PMID: 23343762
PANK deficiency leads to abnormalities in F-actin organization. PMID: 22912811
molecular cloning and characterization of a new human PanK gene PMID: 11809413
alternative splicing product PMID: 12379284
PPARalpha transcription factor as a major factor governing hepatic CoA levels by specific modulation of PANK1alpha gene expression PMID: 14523052
analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration PMID: 17631502

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Subcellular Location

Cytoplasm.; [Isoform 1]: Nucleus. Nucleus, nucleolus.; [Isoform 2]: Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome.

Protein Families

Type II pantothenate kinase family

Tissue Specificity

[Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis.; [Isoform 2]: Detected at much lower levels in kidney, liver, brain and testis and not detected in heart or skeletal muscle.

Database Links

HGNC: 8598

OMIM: 606160

KEGG: hsa:53354

STRING: 9606.ENSP00000302108

UniGene: Hs.163555

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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