PAOX Antibody

Code CSB-PA004746
Size US$100
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  • Western Blot analysis of rat stomach K562 cells using PAOX Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
PAOX
Alternative Names
PAOX antibody; PAO antibody; UNQ1923/PRO4398Peroxisomal N(1)-acetyl-spermine/spermidine oxidase antibody; EC 1.5.3.13 antibody; Polyamine oxidase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human PAOX.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Gene References into Functions
  1. copy number gain in the polyamine oxidase (PAOX) gene locus was accompanied by a coordinated transcriptional up-regulation in Primary myelofibrosis patients PMID: 26547506
  2. PAO activity in children with type 1 diabetes mellitus was very high; higher blood HbA(1C) and MDA levels confirm the presence of oxidant stress demonstrate that PAO activity may participate in these circumstances PMID: 20405312
  3. polyamine oxidase degrades alpha-methylpolyamines in a stereospecific manner PMID: 16354669
Subcellular Location
Peroxisome. Cytoplasm.
Protein Families
Flavin monoamine oxidase family
Tissue Specificity
Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.
Database Links

HGNC: 20837

OMIM: 615853

KEGG: hsa:196743

STRING: 9606.ENSP00000278060

UniGene: Hs.501578

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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