PAPSS2 Antibody

Datasheet

Code	CSB-PA527262LA01HU
Size	US$166
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Image	Immunofluorescence staining of MCF-7 cells with CSB-PA527262LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PAPSS2 Polyclonal antibody

Uniprot No.

O95340

Target Names

PAPSS2

Alternative Names

PAPSS2 antibody; ATPSK2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antibody; PAPS synthase 2 antibody; PAPSS 2 antibody; Sulfurylase kinase 2 antibody; SK 2 antibody; SK2) [Includes: Sulfate adenylyltransferase antibody; EC 2.7.7.4 antibody; ATP-sulfurylase antibody; Sulfate adenylate transferase antibody; SAT); Adenylyl-sulfate kinase antibody; EC 2.7.1.25 antibody; 3'-phosphoadenosine-5'-phosphosulfate synthase antibody; APS kinase antibody; Adenosine-5'-phosphosulfate 3'-phosphotransferase antibody; Adenylylsulfate 3'-phosphotransferase)] antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 protein (2-138AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PAPSS2 Antibody (Product code: CSB-PA527262LA01HU) is Non-conjugated. For PAPSS2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA527262LB01HU	PAPSS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA527262LC01HU	PAPSS2 Antibody, FITC conjugated
Biotin	CSB-PA527262LD01HU	PAPSS2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. Plays indirectly an important role in skeletogenesis during postnatal growth.

Gene References into Functions

In an Amish population, using expression profiling of genes within regions identified by a meta-analysis GWAS of survival to age 90, we localized PAPSS2 as a candidate gene for extended life span. These results provide novel evidence for genetic loci implicated in longevity and incorporate gene expression results from a unique population to locate positional candidates. PMID: 26896383
Silencing of SULT1A1 and PAPSS2 led to a significant decrease in aristolactam-DNA levels in both cell lines following exposure to AA-I, indicating the critical role for sulfonation in the activation of AA-I in vivo Since HK-2 cells proved relatively resistant to knockdown with siRNAs PMID: 27207664
Our results indicate that FGFR2 and PAPSS2 may play an important role in the regulation of magnesium homeostasis in children of European-American ancestry. PMID: 26685716
Results suggest that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy. PMID: 25679447
Direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation. PMID: 25594860
PAPSS2-brachyolmia includes phenotypes of the conventional clinical concept of brachyolmia, the Hobaek and Toledo types, and is associated with abnormal androgen metabolism. PMID: 23824674
Papss2 expression is reduced in articular cartilage following transforming growth factor-beta administration. PMID: 22394585
PAPSS2 is the disease gene for an autosomal recessive brachyolmia. PMID: 22791835
Unusual localisation signals of both PAPS synthase isoforms, are described. PMID: 22242175
Thirty-seven novel SNPs in the PAPSS2 gene and in two intergenic regions on chromosomes 2q33.1 and 18p11.32 were associated with exercise participation. PMID: 19727025
Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2. PMID: 11931653

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Involvement in disease

Brachyolmia type 4 with mild epiphyseal and metaphyseal changes (BCYM4)

Protein Families

APS kinase family; Sulfate adenylyltransferase family

Tissue Specificity

Expressed in cartilage and adrenal gland.

Database Links

HGNC: 8604

OMIM: 603005

KEGG: hsa:9060

STRING: 9606.ENSP00000406157

UniGene: Hs.524491

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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