PAPSS2 Antibody

Code CSB-PA527262LA01HU
Size US$166
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  • Immunofluorescence staining of MCF-7 cells with CSB-PA527262LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PAPSS2 Polyclonal antibody
Uniprot No.
Target Names
PAPSS2
Alternative Names
PAPSS2 antibody; ATPSK2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antibody; PAPS synthase 2 antibody; PAPSS 2 antibody; Sulfurylase kinase 2 antibody; SK 2 antibody; SK2) [Includes: Sulfate adenylyltransferase antibody; EC 2.7.7.4 antibody; ATP-sulfurylase antibody; Sulfate adenylate transferase antibody; SAT); Adenylyl-sulfate kinase antibody; EC 2.7.1.25 antibody; 3'-phosphoadenosine-5'-phosphosulfate synthase antibody; APS kinase antibody; Adenosine-5'-phosphosulfate 3'-phosphotransferase antibody; Adenylylsulfate 3'-phosphotransferase)] antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 protein (2-138AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PAPSS2 Antibody (Product code: CSB-PA527262LA01HU) is Non-conjugated. For PAPSS2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA527262LB01HU PAPSS2 Antibody, HRP conjugated ELISA
FITC CSB-PA527262LC01HU PAPSS2 Antibody, FITC conjugated
Biotin CSB-PA527262LD01HU PAPSS2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. Plays indirectly an important role in skeletogenesis during postnatal growth.
Gene References into Functions
  1. In an Amish population, using expression profiling of genes within regions identified by a meta-analysis GWAS of survival to age 90, we localized PAPSS2 as a candidate gene for extended life span. These results provide novel evidence for genetic loci implicated in longevity and incorporate gene expression results from a unique population to locate positional candidates. PMID: 26896383
  2. Silencing of SULT1A1 and PAPSS2 led to a significant decrease in aristolactam-DNA levels in both cell lines following exposure to AA-I, indicating the critical role for sulfonation in the activation of AA-I in vivo Since HK-2 cells proved relatively resistant to knockdown with siRNAs PMID: 27207664
  3. Our results indicate that FGFR2 and PAPSS2 may play an important role in the regulation of magnesium homeostasis in children of European-American ancestry. PMID: 26685716
  4. Results suggest that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy. PMID: 25679447
  5. Direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation. PMID: 25594860
  6. PAPSS2-brachyolmia includes phenotypes of the conventional clinical concept of brachyolmia, the Hobaek and Toledo types, and is associated with abnormal androgen metabolism. PMID: 23824674
  7. Papss2 expression is reduced in articular cartilage following transforming growth factor-beta administration. PMID: 22394585
  8. PAPSS2 is the disease gene for an autosomal recessive brachyolmia. PMID: 22791835
  9. Unusual localisation signals of both PAPS synthase isoforms, are described. PMID: 22242175
  10. Thirty-seven novel SNPs in the PAPSS2 gene and in two intergenic regions on chromosomes 2q33.1 and 18p11.32 were associated with exercise participation. PMID: 19727025
  11. Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2. PMID: 11931653

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Involvement in disease
Brachyolmia type 4 with mild epiphyseal and metaphyseal changes (BCYM4)
Protein Families
APS kinase family; Sulfate adenylyltransferase family
Tissue Specificity
Expressed in cartilage and adrenal gland.
Database Links

HGNC: 8604

OMIM: 603005

KEGG: hsa:9060

STRING: 9606.ENSP00000406157

UniGene: Hs.524491

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