PATZ1 Antibody

1. The results of IHC and qPCR analyses showed that the expression of PATZ1 in cancerous tissue was significantly lower than that in non-cancerous tissues. Meanwhile, PATZ1 expression was significantly associated with tumor differentiation and LN metastasis. PMID: 29926841
2. ZNF278 played a prominent role in the pathogenesis of colorectal cancer (CRC), and promoted CRC cell proliferation via the ERK/MAPK pathway, suggesting that it may act as a potential target in the diagnosis or treatment of CRC PMID: 29039562
3. this study show that PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas PMID: 27494852
4. Our results suggest that PATZ1 and PP4R2 provide negative feedback on IKK/NF-kappaB signaling to prevent cancer cells from over-stimulation from cellular stimuli PMID: 27391343
5. The derived allele of rs174557, which is the common variant in most populations, diminishes binding of PATZ1, a transcription factor conferring allele-specific downregulation of FADS1. PMID: 27932482
6. Loss of PATZ1 expression is associated with thyroid cancer progression. PMID: 25595894
7. Results show that PATZ1 binds to p53 and inhibits p53-dependent transcription activation. PMID: 25755280
8. these results propose that Patz1 is important for ESC pluripotency. PMID: 24380431
9. The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53-dependent transcription and apoptosis. PMID: 24336083
10. PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging. PMID: 22052190
11. these results showed a potentially novel mechanism of cAMP signaling mediated through the interaction of RIalpha with PATZ1. PMID: 20026299
12. We report here the isolation and characterization of two novel nuclear BTB/POZ domain zinc finger isoformsthat are specifically expressed in early hippocampal neurons, cerebellar granule cells, and gliogenic progenitors as well as in differentiated glia PMID: 11744704
13. MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF PMID: 11751862
14. The results show that ZNF278 promotes cell growth, and its knockdown suppresses cell proliferation. ZNF278 could be a potential proto-oncogene in colorectal cancer. PMID: 18401526
15. The short isoform of the Zinc finger Sarcoma Gene (ZSG) was isolated as a RNF4 interacting protein. PMID: 10949935

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HGNC: 13071

OMIM: 605165

KEGG: hsa:23598

STRING: 9606.ENSP00000266269

UniGene: Hs.731398