PAXBP1 Antibody

Code CSB-PA003778GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PAXBP1
Alternative Names
BM 020 antibody; BM020 antibody; Chromosome 21 open reading frame 66 antibody; FSAP105 antibody; Functional spliceosome-associated protein 105 antibody; GC rich sequence DNA binding factor candidate antibody; GC-rich sequence DNA-binding factor 1 antibody; GCFC antibody; GCFC1 antibody; GCFC1_HUMAN antibody; PAX3 and PAX7 binding protein 1 antibody; PAXBP1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human C21orf66
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20.
Gene References into Functions
  1. A homozygous potentially pathogenic variant in the PAXBP1 gene in a large family with global developmental delay and myopathic hypotonia has been reported. PMID: 28542722
  2. The GCFC1/C21orf66 distal promoter contains an inhibitory cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
Subcellular Location
Nucleus.
Protein Families
GCF family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 13579

OMIM: 617621

KEGG: hsa:94104

STRING: 9606.ENSP00000328992

UniGene: Hs.644004

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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