PCDH11X Antibody

Datasheet

Code	CSB-PA866326LA01HU
Size	US$166
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Image	IHC image of CSB-PA866326LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of HepG2 cells with CSB-PA866326LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PCDH11X Polyclonal antibody

Uniprot No.

Q9BZA7

Target Names

PCDH11X

Alternative Names

PC11X_HUMAN antibody; PCDH-X antibody; PCDH11 antibody; PCDH11X antibody; PCDHX antibody; PPP1R119 antibody; Protein phosphatase 1 regulatory subunit 119 antibody; Protocadherin 11X antibody; Protocadherin on the X chromosome antibody; Protocadherin-11 antibody; Protocadherin-11 X-linked antibody; Protocadherin-S antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protocadherin-11 X-linked protein (987-1117AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PCDH11X Antibody (Product code: CSB-PA866326LA01HU) is Non-conjugated. For PCDH11X Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA866326LB01HU	PCDH11X Antibody, HRP conjugated	ELISA
FITC	CSB-PA866326LC01HU	PCDH11X Antibody, FITC conjugated
Biotin	CSB-PA866326LD01HU	PCDH11X Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Potential calcium-dependent cell-adhesion protein.

Gene References into Functions

PCDH11X, expressed in brain is implicated in cell-cell communication, verbal ability, cerebral asymmetry, and dendritic synaptic plasticity, may be regarded as a new candidate gene for dyslexia. PMID: 24591081
PCDH11X expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive. PMID: 22744706
the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens PMID: 23600975
our data...failed to confirm the association between PCDH11X polymorphisms and late-onset Alzheimer's disease PMID: 21276771
An association between late-onset Alzheimer disease and the PCDH11X polymorphisms, was not detected. PMID: 20523261
PCDH11X gene polymorphism does not play a major role in the genetic predisposition to late-onset Alzheimer disease in this Han Chinese population. PMID: 20707987
association not found for rs5984894 polymorphism in PCDH11X in Alzheimer's disease in Italy PMID: 20555150
The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. PMID: 19859901
By confirming the suspected lack of X-Y homologous status for PCDH11 in non-human primates, our results reinforce the hypothesis of a hominid-specific role for this gene in brain development PMID: 16825765
We consider that a stronger case can be mounted for the Protocadherin11X/Y gene pair located in the hominid specific Xq21.3/Yp11.2 region of homology that was generated by a duplication from the X PMID: 19125366
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. PMID: 19136949
This paper proposes that the PCDH11X/Y gene pair generates epigenetic diversity relating to the species capacity for language including predisposition to psychosis. PMID: 18502103
a candidate for the evolution of hominid-specific characteristics including the sexual dimorphism of cerebral asymmetry, a putative correlate of language PMID: 16874762

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.

Database Links

HGNC: 8656

OMIM: 300246

KEGG: hsa:27328

STRING: 9606.ENSP00000362186

UniGene: Hs.655673

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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