Recombinant Human Protocadherin-11 X-linked (PCDH11X), partial

Code CSB-YP866326HU
MSDS
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Source Yeast
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Code CSB-EP866326HU
MSDS
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Source E.coli
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Code CSB-EP866326HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP866326HU
MSDS
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Source Baculovirus
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Code CSB-MP866326HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PCDH11X
Uniprot No.
Alternative Names
PC11X_HUMAN; PCDH-X; PCDH11; PCDH11X; PCDHX; PPP1R119; Protein phosphatase 1 regulatory subunit 119; Protocadherin 11X; Protocadherin on the X chromosome; Protocadherin-11; Protocadherin-11 X-linked; Protocadherin-S
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Potential calcium-dependent cell-adhesion protein.
Gene References into Functions
  1. PCDH11X, expressed in brain is implicated in cell-cell communication, verbal ability, cerebral asymmetry, and dendritic synaptic plasticity, may be regarded as a new candidate gene for dyslexia. PMID: 24591081
  2. PCDH11X expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive. PMID: 22744706
  3. the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens PMID: 23600975
  4. our data...failed to confirm the association between PCDH11X polymorphisms and late-onset Alzheimer's disease PMID: 21276771
  5. An association between late-onset Alzheimer disease and the PCDH11X polymorphisms, was not detected. PMID: 20523261
  6. PCDH11X gene polymorphism does not play a major role in the genetic predisposition to late-onset Alzheimer disease in this Han Chinese population. PMID: 20707987
  7. association not found for rs5984894 polymorphism in PCDH11X in Alzheimer's disease in Italy PMID: 20555150
  8. The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. PMID: 19859901
  9. By confirming the suspected lack of X-Y homologous status for PCDH11 in non-human primates, our results reinforce the hypothesis of a hominid-specific role for this gene in brain development PMID: 16825765
  10. We consider that a stronger case can be mounted for the Protocadherin11X/Y gene pair located in the hominid specific Xq21.3/Yp11.2 region of homology that was generated by a duplication from the X PMID: 19125366
  11. Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. PMID: 19136949
  12. This paper proposes that the PCDH11X/Y gene pair generates epigenetic diversity relating to the species capacity for language including predisposition to psychosis. PMID: 18502103
  13. a candidate for the evolution of hominid-specific characteristics including the sexual dimorphism of cerebral asymmetry, a putative correlate of language PMID: 16874762

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.
Database Links

HGNC: 8656

OMIM: 300246

KEGG: hsa:27328

STRING: 9606.ENSP00000362186

UniGene: Hs.655673

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