PCGF2 Antibody

1. Low expression of Mel-18 is correlated with gastric cancer. PMID: 27542229
2. Mel-18 underexpression in luminal breast cancer cells caused ER-alpha downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 transactivators p53 and SP1. PMID: 25822021
3. It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression. PMID: 24964959
4. Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer. PMID: 23474752
5. PCGF2, a PRC1 gene, played a negative role in the granulocytic differentiation of human APL cells. PMID: 22085718
6. these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer. PMID: 21602890
7. Loss of Mel-18 is associated with prostate cancer. PMID: 19395284
8. Our analysis showed correlation between BMI1 and PCGF2 gene's expression and survival in children with medulloblastoma. PMID: 20717685
9. Bmi-1/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy. PMID: 21162745
10. Mel-18 may serve as a useful marker in prognostic evaluation for patients with breast cancer. PMID: 20444850
11. Decreased Mel-18 and increased Bmi-1 mRNA expression was associated with the carcinogenesis and progression of gastric cancer PMID: 21059209
12. An association of Mel18 with emerin was observed in Hutchinson-Gilford progeria syndrome, but not in WT cells. PMID: 19727227
13. Mel-18 plays a significant role in the angiogenic function of endothelial cells by regulating endothelial gene expression. PMID: 20801102
14. BMI1 acts as an oncogene and Mel-18 functions as a tumor suppressor via downregulation of BMI1. PMID: 20170541
15. The oncogenic role of MEL-18 in human primary breast carcinomas is determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity. PMID: 17145810
16. Our data suggest that Mel-18 regulates Bmi-1 expression during senescence via down-regulation of c-Myc. PMID: 17151361
17. These results suggest that Bmi-1 and Mel-18 may have overlapping functions in cancer cell growth. PMID: 17452456
18. Mel-18 and Bmi-1 may regulate the Akt pathway in breast cancer cells, and that Mel-18 functions as a tumor suppressor by repressing the expression of Bmi-1 and consequently down-regulating Akt activity. PMID: 17545584
19. Results show that a phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. PMID: 17936708
20. The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1. PMID: 18706886
21. Single Nucleotide Polymorphism and down regulation of Mel-18 is associated with prostate cancer. PMID: 19585577
22. validated occurrence of an unusual TG 3' splice site in intron 1 PMID: 17672918
23. The mouse counterpart of this gene regulates the expression of Th2 cytokines, and plays a critical role in Th2 cell differentiation and Th-2 dependent immune responses. PMID: 11520462
24. The mouse counterpart of this gene regulates the expression of various chemokines and chemokine receptors, which may be important for T cell migration and differentiation. PMID: 11750047

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HGNC: 12929

OMIM: 600346

KEGG: hsa:7703

STRING: 9606.ENSP00000354033

UniGene: Hs.371617