PDE1A Antibody, Biotin conjugated

Code CSB-PA22739D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDE1A Polyclonal antibody
Uniprot No.
Target Names
PDE1A
Alternative Names
3' 5' cyclic nucleotide phosphodiesterase antibody; 5''-cyclic nucleotide phosphodiesterase 1A antibody; 61 kDa Cam PDE antibody; 61 kDa Cam-PDE antibody; Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody; Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase antibody; Calcium/calmodulin-dependent 3'' antibody; Calmodulin-dependent Phosphodiesterase antibody; Cam PDE 1A antibody; Cam-PDE 1A antibody; CAM-PDE-1A antibody; HCAM 1 antibody; hCam-1 antibody; HCAM1 antibody; HSPDE1A antibody; MGC26303 antibody; PDE 1A antibody; PDE1A antibody; PDE1A_HUMAN antibody; Phosphodiesterase 1A antibody; Phosphodiesterase 1A calmodulin dependent antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Calcium/calmodulin-dependent 3\',5\'-cyclic nucleotide phosphodiesterase 1A protein (1-219AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Gene References into Functions
  1. evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts. PMID: 29262781
  2. Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness. PMID: 26464516
  3. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis PMID: 22012077
  4. PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1. PMID: 20807569
  5. PDE1A is permanently activated in human spermatozoa PMID: 12135876
  6. Ca2+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2+ PMID: 15272012
  7. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis. PMID: 16514069
  8. Variants in PDE1A are not associated with citalopram response in patient with depression. PMID: 18043711
  9. PDE1A is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142

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Protein Families
Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
Tissue Specificity
Several tissues, including brain, kidney, testes and heart.
Database Links

HGNC: 8774

OMIM: 171890

KEGG: hsa:5136

STRING: 9606.ENSP00000331574

UniGene: Hs.191046

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