PDE1A Antibody

Datasheet

Code	CSB-PA22739A0Rb
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA22739A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PDE1A Polyclonal antibody

Uniprot No.

P54750

Target Names

PDE1A

Alternative Names

3' 5' cyclic nucleotide phosphodiesterase antibody; 5''-cyclic nucleotide phosphodiesterase 1A antibody; 61 kDa Cam PDE antibody; 61 kDa Cam-PDE antibody; Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody; Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase antibody; Calcium/calmodulin-dependent 3'' antibody; Calmodulin-dependent Phosphodiesterase antibody; Cam PDE 1A antibody; Cam-PDE 1A antibody; CAM-PDE-1A antibody; HCAM 1 antibody; hCam-1 antibody; HCAM1 antibody; HSPDE1A antibody; MGC26303 antibody; PDE 1A antibody; PDE1A antibody; PDE1A_HUMAN antibody; Phosphodiesterase 1A antibody; Phosphodiesterase 1A calmodulin dependent antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Calcium/calmodulin-dependent 3\',5\'-cyclic nucleotide phosphodiesterase 1A protein (1-219AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PDE1A Antibody (Product code: CSB-PA22739A0Rb) is Non-conjugated. For PDE1A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA22739B0Rb	PDE1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA22739C0Rb	PDE1A Antibody, FITC conjugated
Biotin	CSB-PA22739D0Rb	PDE1A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

Gene References into Functions

evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts. PMID: 29262781
Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness. PMID: 26464516
These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis PMID: 22012077
PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1. PMID: 20807569
PDE1A is permanently activated in human spermatozoa PMID: 12135876
Ca2+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2+ PMID: 15272012
PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis. PMID: 16514069
Variants in PDE1A are not associated with citalopram response in patient with depression. PMID: 18043711
PDE1A is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142

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Protein Families

Cyclic nucleotide phosphodiesterase family, PDE1 subfamily

Tissue Specificity

Several tissues, including brain, kidney, testes and heart.

Database Links

HGNC: 8774

OMIM: 171890

KEGG: hsa:5136

STRING: 9606.ENSP00000331574

UniGene: Hs.191046

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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