PDE8A Antibody

1. SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq PMID: 27560698
2. PDE8A supports HIV-1 replication in macrophages PMID: 25295610
3. a novel and critical role for phosphodiesterases in moderating local concentrations of cAMP in microdomains and signal resetting PMID: 25229150
4. PDE8A can bind tightly to Raf-1, regulate Raf-1 phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 signaling, retarding subsequent ERK phosphorylation and activation. PMID: 23509299
5. PDE8 activity can be modulated by a kinase PMID: 22673573
6. Polymorphism in PDE8A affects HIV-1 replication in primary macrophages. PMID: 21920574
7. Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A. PMID: 12681444
8. in vitro and in vivo experiments demonstrated that the association with IkappaB greatly enhanced the enzyme activity of PDE8A1 PMID: 15596729
9. kinetic properties of the highly active PDE8A1 catalytic domain prepared from refolding and its crystal structures in the unliganded and 3-isobutyl-1-methylxanthine (IBMX) bound forms at 1.9 and 2.1 A resolutions PMID: 18983167
10. The findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las major determinant of androgen levels in women. PMID: 19482904

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HGNC: 8793

OMIM: 602972

KEGG: hsa:5151

STRING: 9606.ENSP00000311453

UniGene: Hs.9333