PHACTR4 Antibody

Datasheet

Code	CSB-PA017883GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8IZ21

Target Names

PHACTR4

Alternative Names

Phactr4 antibody; PHAR4_HUMAN antibody; Phosphatase and actin regulator 4 antibody; PRO2963 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PHACTR4

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.

Gene References into Functions

Data indicate that Phactr4 acts as a tumor suppressor that is deleted and mutant in several cancers. PMID: 23319639
The authors show that rat Phactr1 inhibits PP1 activity in vitro, and mouse Phactr4 coimmunoprecipitates with actin and PP1 in human cells. PMID: 15107502

Subcellular Location

Cytoplasm. Cell projection, lamellipodium.

Protein Families

Phosphatase and actin regulator family

Database Links

HGNC: 25793

OMIM: 608726

KEGG: hsa:65979

UniGene: Hs.225641

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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