PLP2 Antibody

Code CSB-PA018203GA01HU
Size US$685
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Product Details

Uniprot No. Q04941
Target Names PLP2
Alternative Names PLP2 antibody; A4 antibody; Proteolipid protein 2 antibody; Differentiation-dependent protein A4 antibody; Intestinal membrane A4 protein antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human PLP2
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
May play a role in cell differentiation in the intestinal epithelium.
Gene References into Functions
  1. PLP2 specifically binds to phosphatidylinositol 3 kinase to activate the protein kinase B pathway to enhance cell proliferation, adhesion, and invasion in melanoma cells. PMID: 26287415
  2. miR-664 negatively regulates PLP2 and promotes proliferation and invasion of T-ALL cell lines. Thus, miR-664 may represent a potential therapeutic target for T-ALL intervention. PMID: 25735976
  3. PLP2 and RAB5C are binding partners of TPD52. PMID: 24604726
  4. This work ascribes a critical function to PLP2 for viral ligase activity and underlines the power of non-lethal haploid genetic screens in human cells to identify the genes involved in pathogen manipulation of the host immune system. PMID: 24278019
  5. PLP2/A4 has a role in the chemotactic processes via CCR1 PMID: 15474493
  6. PLP2 is expressed abundantly in the pyramidal cells of hippocampus and granular cells of the cerebellum in the brains of a cohort of males with probable X-linked mental retardation. PMID: 17416750

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Subcellular Location Membrane, Multi-pass membrane protein
Tissue Specificity Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.
Database Links

HGNC: 9087

OMIM: 300112

KEGG: hsa:5355

STRING: 9606.ENSP00000365505

UniGene: Hs.77422

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