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PLSCR4 Antibody

Datasheet
Code CSB-PA018210GA01HU
Size $600
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Product Details

Uniprot No.
Q9NRQ2
Target Names
PLSCR4
Alternative Names
AV245873 antibody; Ca(2+)-dependent phospholipid scramblase 4 antibody; Cell growth inhibiting protein 43 antibody; Cell growth-inhibiting gene 43 protein antibody; GIG43 antibody; Phospholipid scramblase 4 antibody; PL scramblase 4 antibody; Pls4 antibody; PLS4_HUMAN antibody; Plscr4 antibody; TRA1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PLSCR4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Gene References into Functions
  1. the first report on the transcriptional regulation of hPLSCR4, where Snail was shown to downregulate the expression of Human phospholipid scramblase 4 PMID: 27363667
  2. biochemical and functional characterization of human phospholipid scramblase 4 PMID: 23089641
  3. Crystallographic analysis of mammalian importin alpha1 in complex with the hPLSCR4-NLS reveals this minimal NLS binds specifically and exclusively to the minor binding site of importin alpha PMID: 21690087
  4. SLPI is a ligand for PLSCR1 and PLSCR4, which also interact directly with the CD4 receptor at the cell surface of T lymphocytes PMID: 19333378
Subcellular Location
Membrane; Single-pass type II membrane protein.
Protein Families
Phospholipid scramblase family
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.
Database Links

HGNC: 16497

OMIM: 607612

KEGG: hsa:57088

STRING: 9606.ENSP00000347038

UniGene: Hs.477869

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