PMP2 Antibody

Datasheet

Code	CSB-PA094064
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA094064(PMP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA094064(PMP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse fat tissue, Primary antibody: CSB-PA094064(PMP2 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 80 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P02689

Target Names

PMP2

Alternative Names

FABP8 antibody; M FABP antibody; MP2 antibody; Myelin FABP antibody; Myelin P2 protein antibody; MYP2_HUMAN antibody; P2 antibody; Peripheral myelin protein 2 antibody; PMP2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Full length fusion protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

May play a role in lipid transport protein in Schwann cells. May bind cholesterol.

Gene References into Functions

The structural characterization of the F57A mutant of P2 which shows changes in the portal region and helix alpha2 and an unfolded status upon lipid bilayer binding. Further results suggest a central role for Phe57 in regulating the opening of the portal region in human P2, and the F57A mutation disturbs dynamic cross-correlation networks in the portal region of P2. PMID: 29940944
SH3TC2, PMP2, and BSCL2 pathogenic variants might be rare in Chinese Charcot-Marie-Tooth (CMT) patients. PMID: 29336362
Our genetic and clinical findings in these kindred demonstrate that dominant PMP2 mutations cause Charcot-Marie- Tooth disease type 1. PMID: 27009151
A fully deuterated sample of myelin P2 protein was produced identifying the neutron crystal structure. PMID: 26527266
This report might expand the genetic and clinical features of Charcot-Marie-Tooth disease and a further mechanism study will enhance our understanding of PMP2-associated peripheral neuropathy. PMID: 26828946
The structure of human P2 refined at the ultrahigh resolution of 0.93 A allows detailed structural analyses, including the full organization of an internal hydrogen-bonding network. PMID: 24419389
the structure and function of the P2 protein from human myelin, which is able to bind both monomeric lipids inside its cavity and membrane surfaces PMID: 20421974

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Subcellular Location

Cytoplasm.

Protein Families

Calycin superfamily, Fatty-acid binding protein (FABP) family

Database Links

HGNC: 9117

OMIM: 170715

KEGG: hsa:5375

STRING: 9606.ENSP00000256103

UniGene: Hs.571512

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Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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