PMVK Antibody

Datasheet

Code	CSB-PA018258GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q15126

Target Names

PMVK

Alternative Names

hPMK antibody; HUMPMKI antibody; OTTHUMP00000035546 antibody; Phosphomevalonate kinase antibody; PMK antibody; PMK PEN antibody; PMKA antibody; PMKase antibody; PMKI antibody; PMKPEN antibody; PMVK antibody; PMVK_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PMVK

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.

Gene References into Functions

Data indicate that exome sequencing revealed disseminated superficial porokeratosis (DSP)-associated mutations in phosphomevalonate kinase gene (PMVK). PMID: 27052676
found an exclusive cytosolic localization of both endogenously expressed PMVK(in human fibroblasts, human liver, and HEK293 cells) and overexpressed PMVK. No indication of a peroxisomal localization was obtained. PMID: 14729858
Functional evaluation of conserved basic residues in PMVK is reported. PMID: 17902708
This is the first report of hPMK crystal structure that suggests a potential substrate binding site and a possible enzyme catalytic mechanism. PMID: 18618710
Binding of mevalonate 5-phosphate causes the phosphomevalonate kinase structure to compress (tau(c) = 13.5 nsec), whereas subsequent binding of Mg-ADP opens the structure up (tau(c) = 15.6 nsec). PMID: 18798562

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Involvement in disease

Porokeratosis 1, multiple types (POROK1)

Subcellular Location

Cytoplasm, cytosol.

Tissue Specificity

Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.

Database Links

HGNC: 9141

OMIM: 175800

KEGG: hsa:10654

STRING: 9606.ENSP00000357452

UniGene: Hs.30954

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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