PNPLA6 Antibody

Datasheet
Code CSB-PA809011LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q8IY17
Image
  • IHC image of CSB-PA809011LA01HU diluted at 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA809011LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Neuropathy target esterase protein (345-493AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200
Relevance Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Neuropathy target esterase (EC 3.1.1.5) (Patatin-like phospholipase domain-containing protein 6), PNPLA6, NTE
Immunogen Species Human
Research Area Neuroscience
Target Names PNPLA6
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Involvement in disease Spastic paraplegia 39, autosomal recessive (SPG39); Boucher-Neuhauser syndrome (BNHS); Laurence-Moon syndrome (LNMS); Oliver-McFarlane syndrome (OMCS)
Subcellular Location Endoplasmic reticulum membrane, Single-pass type I membrane protein, Cytoplasmic side
Protein Families NTE family
Tissue Specificity Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.
Database Links

HGNC: 16268

OMIM: 215470

KEGG: hsa:10908

STRING: 9606.ENSP00000407509

UniGene: Hs.631863

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