PNPLA8 Antibody

Code CSB-PA003057
Size US$167
Image
  • Western Blot analysis of HeLa cells using iPLA2γ Polyclonal Antibody
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Product Details

Uniprot No. Q9NP80
Target Names PNPLA8
Alternative Names Calcium-independent phospholipase A2-gamma antibody; Intracellular membrane associated calcium independent phospholipase A2 gamma antibody; Intracellular membrane-associated calcium-independent phospholipase A2 gamma antibody; IPLA2 2 antibody; iPLA2 gamma antibody; IPLA2(GAMMA) antibody; iPLA2-2 antibody; iPLA2-gamma antibody; IPLA22 antibody; IPLA2G antibody; Patatin like phospholipase domain containing protein 8 antibody; Patatin-like phospholipase domain-containing protein 8 antibody; PLPL8_HUMAN antibody; PNPLA-gamma antibody; PNPLA8 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the C-terminal region of Human iPLA2γ.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.
Gene References into Functions
  1. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. PMID: 29158256
  2. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation. PMID: 25313821
  3. iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease. PMID: 23429536
  4. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma. PMID: 23258543
  5. These results suggest distinct roles for iPLA2beta and iPLA2gamma in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution of iPLA2gamma to tumorigenesis. PMID: 15695510
  6. iPLA2 activation is not sufficient for SOCE activation. iPLA2 may regulate basal phosphoinositide metabolism PMID: 18680539

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Involvement in disease Mitochondrial myopathy with lactic acidosis (MMLA)
Subcellular Location Endoplasmic reticulum membrane, Single-pass membrane protein, Golgi apparatus membrane, Single-pass membrane protein, Cytoplasm, perinuclear region
Tissue Specificity Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
Database Links

HGNC: 28900

OMIM: 251950

KEGG: hsa:50640

STRING: 9606.ENSP00000257694

UniGene: Hs.617340

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