POC5 Antibody, HRP conjugated

Code CSB-PA843309LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) POC5 Polyclonal antibody
Uniprot No.
Target Names
POC5
Alternative Names
C5orf37 antibody; Centrosomal protein POC5 antibody; FLJ35779 antibody; hPOC5 antibody; MGC120442 antibody; MGC120443 antibody; MGC120444 antibody; OTTHUMP00000222116 antibody; OTTHUMP00000222453 antibody; Poc5 antibody; POC5 centriolar protein antibody; POC5 centriolar protein homolog (Chlamydomonas) antibody; POC5 centriolar protein homolog antibody; POC5_HUMAN antibody; Protein of centriole 5 antibody; Proteome of centriole 5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Centrosomal protein POC5 protein (373-485AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential for the assembly of the distal half of centrioles, required for centriole elongation.
Gene References into Functions
  1. Common variant rs6892146 of POC5 is associated with the development of adolescent idiopathic scoliosis in the Chinese population. PMID: 29189569
  2. Depletion of CEP295 blocks the incorporation of POC5 and POC1B into the distal portion of centrioles and suppresses the post-translational modification of centriolar microtubules . Our study thus uncovers a new role for CEP295 during centriole elongation. PMID: 27185865
  3. Mutations in the POC5 gene contribute to the occurrence of idiopathic scoliosis. PMID: 25642776
  4. Data indicate that overexpression of the centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures. PMID: 23844208
  5. hPOC5, a conserved centrin-binding protein that contains Sfi1p-like repeats is characterized. PMID: 19349582

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the distal portion of centrioles.
Protein Families
POC5 family
Database Links

HGNC: 26658

OMIM: 617880

KEGG: hsa:134359

STRING: 9606.ENSP00000410216

UniGene: Hs.432726

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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