Recombinant Human Centrosomal protein POC5(POC5)

Code CSB-YP843309HU
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Source Yeast
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Code CSB-EP843309HU
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Source E.coli
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Code CSB-EP843309HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP843309HU
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Source Baculovirus
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Code CSB-MP843309HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names POC5
Uniprot No. Q8NA72
Alternative Names C5orf37; Centrosomal protein POC5; FLJ35779; hPOC5; MGC120442; MGC120443; MGC120444; OTTHUMP00000222116; OTTHUMP00000222453; Poc5; POC5 centriolar protein; POC5 centriolar protein homolog (Chlamydomonas); POC5 centriolar protein homolog; POC5_HUMAN; Protein of centriole 5; Proteome of centriole 5
Species Homo sapiens (Human)
Expression Region 1-575
Target Protein Sequence MSSDEEKYSL PVVQNDSSRG SSVSSNLQEE YEELLHYAIV TPNIEPCASQ SSHPKGELVP DVRISTIHDI LHSQGNNSEV RETAIEVGKG CDFHISSHSK TDESSPVLSP RKPSHPVMDF FSSHLLADSS SPATNSSHTD AHEILVSDFL VSDENLQKME NVLDLWSSGL KTNIISELSK WRLNFIDWHR MEMRKEKEKH AAHLKQLCNQ INELKELQKT FEISIGRKDE VISSLSHAIG KQKEKIELMR TFFHWRIGHV RARQDVYEGK LADQYYQRTL LKKVWKVWRS VVQKQWKDVV ERACQARAEE VCIQISNDYE AKVAMLSGAL ENAKAEIQRM QHEKEHFEDS MKKAFMRGVC ALNLEAMTIF QNRNDAGIDS TNNKKEEYGP GVQGKEHSAH LDPSAPPMPL PVTSPLLPSP PAAVGGASAT AVPSAASMTS TRAASASSVH VPVSALGAGS AATAASEEMY VPRVVTSAQQ KAGRTITARI TGRCDFASKN RISSSLAIMG VSPPMSSVVV EKHHPVTVQT IPQATAAKYP RTIHPESSTS ASRSLGTRSA HTQSLTSVHS IKVVD
Protein Length full length protein
Tag Info The following tags are available.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Essential for the assembly of the distal half of centrioles, required for centriole elongation.
Gene References into Functions
  1. Common variant rs6892146 of POC5 is associated with the development of adolescent idiopathic scoliosis in the Chinese population. PMID: 29189569
  2. Depletion of CEP295 blocks the incorporation of POC5 and POC1B into the distal portion of centrioles and suppresses the post-translational modification of centriolar microtubules . Our study thus uncovers a new role for CEP295 during centriole elongation. PMID: 27185865
  3. Mutations in the POC5 gene contribute to the occurrence of idiopathic scoliosis. PMID: 25642776
  4. Data indicate that overexpression of the centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures. PMID: 23844208
  5. hPOC5, a conserved centrin-binding protein that contains Sfi1p-like repeats is characterized. PMID: 19349582

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Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Protein Families POC5 family
Database Links

HGNC: 26658

OMIM: 617880

KEGG: hsa:134359

STRING: 9606.ENSP00000410216

UniGene: Hs.432726

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