POGZ Antibody, HRP conjugated

Datasheet

Code	CSB-PA018299LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) POGZ Polyclonal antibody

Uniprot No.

Q7Z3K3

Target Names

POGZ

Alternative Names

KIAA0461 antibody; MGC71543 antibody; Pogo transposable element with ZNF domain antibody; POGZ antibody; POGZ_HUMAN antibody; putative protein product of Nbla00003 antibody; SUHW5 antibody; suppressor of hairy wing homolog antibody; Suppressor of hairy wing homolog 5 antibody; Zinc finger protein 280E antibody; Zinc finger protein 635 antibody; ZNF280E antibody; ZNF635 antibody; ZNF635M antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pogo transposable element with ZNF domain protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.

Gene References into Functions

In silico analysis and western blotting revealed this frameshift mutation generating truncated protein in peripheral blood lymphocytes, and this may disrupt several important domains of POGZ gene. Our finding broadens the spectrum of POGZ mutations and may help to understand the molecular basis of Intellectual disability (ID) and aid genetic counseling. PMID: 26763879
Data suggest that loss of function variants in POGZ lead to an identifiable syndrome of neurodevelopmental disorders with specific phenotypic traits including intellectual disability. PMID: 26739615
We find that POGZ is constitutively expressed across most tissues and has significantly higher levels of expression in the cerebellum and the pituitary gland. Disruption of POGZ is associated with intellectual disability and autism spectrum disorders PMID: 26942287
The results reveal POGZ as an essential protein that links HP1alpha dissociation with Aurora B kinase activation during mitosis. PMID: 20562864

Involvement in disease

White-Sutton syndrome (WHSUS)

Subcellular Location

Nucleus. Chromosome. Cytoplasm.

Database Links

HGNC: 18801

OMIM: 614787

KEGG: hsa:23126

STRING: 9606.ENSP00000271715

UniGene: Hs.489873

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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