POLR2E Antibody, HRP conjugated

Datasheet

Code	CSB-PA018332LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) POLR2E Polyclonal antibody

Uniprot No.

P19388

Target Names

POLR2E

Alternative Names

and III subunit ABC1 antibody; and III subunit RPABC1 antibody; DNA directed RNA polymerase II 23 kda polypeptide antibody; DNA directed RNA polymerase II 23 kDa polypeptide antibody; DNA directed RNA polymerase II polypeptide E antibody; DNA directed RNA polymerase II subunit E antibody; DNA directed RNA polymerases I II and III subunit RPABC1 antibody; DNA-directed RNA polymerase II 23 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit E antibody; DNA-directed RNA polymerases I antibody; hRPB25 antibody; hsRPB5 antibody; II antibody; Polr2e antibody; Polymerase (RNA) II (DNA directed) polypeptide E (25kD) antibody; Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa antibody; RNA polymerases I antibody; RNA polymerases I, II, and III subunit ABC1 antibody; RPAB1_HUMAN antibody; RPABC1 antibody; RPB5 antibody; RPB5 homolog antibody; XAP4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA-directed RNA polymerases I, II, and III subunit RPABC1 protein (1-210AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.

Gene References into Functions

POLR2E rs3787016T allele was associated with an increased cancer risk in Chinese population PMID: 29724531
POLR2E rs3787016 C/T and HULC rs7763881 were associated with a significantly decreased risk for ESCC 0.005). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC. PMID: 25874495
ELL has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release PMID: 22252557
crystal of RPB5 diffracted to 2.8 A resolution and belonged to space group P4(3)2(1)2. PMID: 22102239
RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. PMID: 21310960
Results pinpoint critical residues for RNA polymerase II subunit 5 binding to RAP30 and/or to HBx, and identify these residues in both mammalian cells and in an in vitro binding assay. PMID: 16169872

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Subcellular Location

Nucleus.

Protein Families

Archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family

Database Links

HGNC: 9192

OMIM: 180664

KEGG: hsa:5434

STRING: 9606.ENSP00000215587

UniGene: Hs.24301

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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