POLR3C Antibody

Datasheet

Code	CSB-PA871578LA01HU
Size	US$166
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Image	Western blot All lanes: POLR3C antibody at 2µg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Mouse brain tissue Lane 4: THP-1 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 61 kDa Observed band size: 61 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) POLR3C Polyclonal antibody

Uniprot No.

Q9BUI4

Target Names

POLR3C

Alternative Names

DNA directed III 62 kDa polypeptide antibody; DNA-directed RNA polymerase III subunit C antibody; DNA-directed RNA polymerase III subunit rpc3 antibody; POLR3C antibody; Polymerase (RNA) III (DNA directed) polypeptide C (62kD) antibody; RNA polymerase C subunit 3 antibody; RNA polymerase III 62 kDa subunit antibody; RNA polymerase III C62 subunit antibody; RNA polymerase III subunit C3 antibody; RPC3 antibody; RPC3_HUMAN antibody; RPC62 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human DNA-directed RNA polymerase III subunit RPC3 protein (1-534AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The POLR3C Antibody (Product code: CSB-PA871578LA01HU) is Non-conjugated. For POLR3C Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA871578LB01HU	POLR3C Antibody, HRP conjugated	ELISA
FITC	CSB-PA871578LC01HU	POLR3C Antibody, FITC conjugated
Biotin	CSB-PA871578LD01HU	POLR3C Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.

Gene References into Functions

monogenic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe VZV disease in otherwise healthy children, providing evidence for an essential role of a DNA sensor in human immunity PMID: 28783042
The study reports the crystal structure of RPC62. PMID: 21358628

Subcellular Location

Nucleus.

Protein Families

Eukaryotic RPC3/POLR3C RNA polymerase subunit family

Database Links

HGNC: 30076

OMIM: 617454

KEGG: hsa:10623

STRING: 9606.ENSP00000334564

UniGene: Hs.515768

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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