POLR3K Antibody

Datasheet

Code	CSB-PA018352HA01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) POLR3K Polyclonal antibody

Uniprot No.

Q9Y2Y1

Target Names

POLR3K

Alternative Names

C11 antibody; C11 RNP3 antibody; DNA directed RNA polymerase III subunit K antibody; DNA directed RNA polymerase III subunit RPC10 antibody; DNA directed RNA polymerases III 12.5 kDa polypeptide antibody; DNA-directed RNA polymerase III subunit K antibody; DNA-directed RNA polymerase III subunit RPC10 antibody; hRPC11 antibody; HsC11p antibody; My010 antibody; POLR3K antibody; Polymerase (RNA) III (DNA directed) polypeptide K antibody; Polymerase (RNA) III (DNA directed) polypeptide K; 12.3 kDa antibody; RNA polymerase III 12.5 kDa subunit antibody; RNA polymerase III subunit (hRPC11) antibody; RNA polymerase III subunit C10 antibody; RNA polymerase III subunit C11 antibody; RNA polymerase III subunit CII antibody; RPC10 antibody; RPC10_HUMAN antibody; RPC11 antibody; RPC12.5 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA-directed RNA polymerase III subunit RPC10 protein (1-108AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The POLR3K Antibody (Product code: CSB-PA018352HA01HU) is Non-conjugated. For POLR3K Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018352HB01HU	POLR3K Antibody, HRP conjugated	ELISA
FITC	CSB-PA018352HC01HU	POLR3K Antibody, FITC conjugated
Biotin	CSB-PA018352HD01HU	POLR3K Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene References into Functions

Results from a study on gene expression variability markers in early-stage human embryos shows that POLR3K is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
Changes in Maf1 expression affect Pol III-dependent transcription in human glioblastoma lines. PMID: 17499043

Subcellular Location

Nucleus, nucleolus.

Protein Families

Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family

Database Links

HGNC: 14121

OMIM: 606007

KEGG: hsa:51728

STRING: 9606.ENSP00000293860

UniGene: Hs.632223

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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