PPM1L Antibody

Code CSB-PA018498GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PPM1L
Alternative Names
PPM1L antibody; PP2CE antibody; Protein phosphatase 1L antibody; EC 3.1.3.16 antibody; Protein phosphatase 1-like antibody; Protein phosphatase 2C isoform epsilon antibody; PP2C-epsilon antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PPM1L
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
Gene References into Functions
  1. Genetic variation at chromosome 3 harbors an element that regulates expression of an upstream candidate tumor suppressor, PPM1L, thus providing a novel mechanism for colorectal tumorigenesis. PMID: 19847890
  2. cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon*) PMID: 15560375
  3. These results suggest that PP2Cepsilon maintains ASK1 in an inactive state by dephosphorylation in quiescent cells, supporting the possibility that PP2Cepsilon and PP5 play different roles in H2O2-induced regulation of ASK1 activity. PMID: 17456047
  4. CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus. PMID: 18165232
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
PP2C family
Tissue Specificity
Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.
Database Links

HGNC: 16381

OMIM: 611931

KEGG: hsa:151742

STRING: 9606.ENSP00000417659

UniGene: Hs.389027

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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