PPP1R3B Antibody, HRP conjugated

Code CSB-PA769802LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PPP1R3B Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
FLJ14005 antibody; FLJ34675 antibody; GL antibody; Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL antibody; Hepatic glycogen targeting subunit G(L) antibody; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL antibody; PP1 subunit R4 antibody; Ppp1r3b antibody; PPP1R4 antibody; PPR3B_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 3B antibody; Protein phosphatase 1 regulatory subunit 3B antibody; Protein phosphatase 1 regulatory subunit 4 antibody; Protein phosphatase 1 subunit 4 antibody; Protein phosphatase 1 subunit GL antibody; PTG antibody; R4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein phosphatase 1 regulatory subunit 3B protein (1-285AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
Gene References into Functions
  1. These observations are consistent with the notion that the minor allele of rs4841132 promotes a mild form of hepatic glycogenosis that is associated with hepatic injury PMID: 29266543
  2. rs9987289 A-allele was associated with plasma lactate in European-Americans but not in African-Americans. PMID: 26433129
  3. Among Mexicans, the PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults. PMID: 27752939
  4. A novel role for PTG in protecting hepatocellular carcinoma cells from metabolic stress, in part by regulating oxidative stress and autophagy. PMID: 26182369
  5. Some, but not all, associations between variants in NCAN, lysophospholipase-like 1, GCKR, and PPP1R3B with hepatic steatosis (with and without increased ALT level) were significant within subpopulations. PMID: 23416328
  6. Data indicate that genetic polymorphisms of the PPP1R3B gene may contribute to variations in plasma lipids and C-reactive protein (CRP) levels among Chinese Han individuals. PMID: 23343124
  7. Results suggest that in cultured human myotubes, glycogen-targeting PP1 (protein phosphatase 1) subunit G(L) (coded for by the PPP1R3B gene) is expressed as in muscle tissue and is unresponsive to glucose or insulin, as are G(M) and PTG genes. PMID: 17555403

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Tissue Specificity
Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expr
Database Links

HGNC: 14942

OMIM: 610541

KEGG: hsa:79660

STRING: 9606.ENSP00000308318

UniGene: Hs.458513

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