PRMT6 Antibody

1. This study indicated that the hypomethylation of PRMT6 promoter could be a novel diagnostic biomarker for colorectal cancer. PMID: 29927001
2. PRMT6 negatively regulates DNA methylation in cancer. PRMT6 overexpression impairs chromatin association of UHRF1, an accessory factor of DNMT1, resulting in passive DNA demethylation. PMID: 29262320
3. Data suggest that histone-arginine N-methyltransferase PRMT6 (PRMT6) plays an oncogenic role in prostate cancer (PCa) and predicts for more clinically aggressive disease, constituting a potential target for patients with Prostate cancer (CRPC). PMID: 27323813
4. Based on the structural information here and available in the PDB database, we proposed a mechanism that can rationalize the distinctive arginine methylation product specificity of different types of arginine methyltransferases and pinpoint the structural determinant of such a specificity PMID: 27480107
5. PRMT6, which was down-regulated by androgen receptors and influenced cell migration and apoptosis of germ cells, could play a potentially important role in spermatogenesis. PMID: 26690413
6. PRMT6 methylates tumor cell p21 at arginine 156 and promotes phosphorylation of threonine 145 on p21, increasing the cytoplasmic localization of p21 and inducing resistance to anticancer drugs. PMID: 26436589
7. PRMT6 influences PRC-mediated gene silencing at the rostral HOXA genes locus. PMID: 26848759
8. Data show that HIV-1 Tat methylation by protein arginine methyltransferase 6 (PRMT6) can inhibit nucleolar retention. PMID: 26611710
9. N terminus is methylated by PRMT6 and that this critically affects the functions of pUL69 for efficient mRNA export and replication of human cytomegalovirus. PMID: 26178996
10. TBL1 is required to protect GPS2 from degradation, with methylation of GPS2 by arginine methyltransferase PRMT6 regulating the interaction with TBL1 and inhibiting proteasome-dependent degradation. PMID: 26070566
11. PRMT6 mediates cigarette smoke extract induced apoptosis and inflammation through H3R2me2a in HUVECs. PMID: 25481537
12. PRMT6 specifically interacts with ERalpha at its ligand-binding domain. PMID: 24742914
13. Authors show that PRMT6 requires the activation domain, but surprisingly not the basic domain, of HIV-1 Tat for protein interaction. PMID: 23800116
14. Data show arginine methyltransferase PRMT6 methylates the AT-hook motif of regulatory factor RFX5 and downregulates HLA-DQ expression. PMID: 23911394
15. Arginine 42 of histone H3 (H3R42), is dimethylated by the methyltransferases coactivator arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro and in vivo. PMID: 23980157
16. these data demonstrate that PRMT6 overexpression is associated with regulation of motility and invasion through up-regulation of TSP-1 and down-regulation of MMPs in human cancer cells. PMID: 23380452
17. These results show that PRMT6 automethylation plays a role in the stability of this protein and that this event is indispensible for its anti-HIV-1 activity. PMID: 23866860
18. PRMT6 is recruited by RUNX1 and mediates asymmetric histone H3 arginine-2 dimethylation (H3R2me2a) at megakaryocytic genes in progenitor cells. PMID: 22777353
19. 36 new putative partners for PRMT6 were identified. PMID: 23326497
20. Findings indicate that expression of PRMT4/CARM1 and PRMT6 is deregulated in melanoma. PMID: 23265702
21. Gene expression and promoter analysis show that p21 and p27 are direct targets of PRMT6, which involves methylation of arginine-2 of histone H3. Our findings imply arginine methylation of histones by PRMT6 in cell cycle regulation PMID: 22916108
22. Specific arginine residues of p16 protein are methylated by PRMT6 which may be critical for the activity of p16. PMID: 23032699
23. dysregulation of PRMT6-dependent transcription and alternative splicing may be involved in breast cancer pathophysiology and the molecular consequences identifying a unique and informative biomarker profile. PMID: 22673335
24. the molecular mechanisms of PRMT catalysis PMID: 22219200
25. In this study, we use Forster resonance energy transfer (FRET) to determine dissociation constant (K(D)) values for dimerization of PRMT1 and PRMT6. PMID: 20812326
26. PRMT6 may be involved in human carcinogenesis and may thus be a therapeutic target for various types of cancer. PMID: 20473859
27. methylates HIV-1 Tat protein and acts as a restriction factor for HIV-1 replication PMID: 15596808
28. severely impairs the function of HIV-1 Rev binding to and export of viral RNA PMID: 17176473
29. findings show HIV-1 Tat is a specific substrate of PRMT6 which targets Tat R52 & R53 residues for arginine methylation; PRMT6 can compromise Tat transcriptional activation & may represent a form of innate cellular immunity in regard to HIV-1 replication PMID: 17267505
30. the arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H3R2me2a in vivo PMID: 17898714
31. PRMT6 methylates H3R2 and is a negative regulator of N-terminal H3 tail binding PMID: 18077460
32. findings identify PRMT6 as the mammalian methyltransferase for H3 R2 and establish the enzyme as a crucial negative regulator of H3 K4 trimethylation and transcriptional activation PMID: 18079182
33. TSP-1 is a transcriptional repression target of PRMT6 PMID: 19509293

Show More

Hide All

HGNC: 18241

OMIM: 608274

KEGG: hsa:55170

STRING: 9606.ENSP00000359095

UniGene: Hs.26006