PLPBP Antibody, Biotin conjugated

Code CSB-PA018755LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLPBP Polyclonal antibody
Uniprot No.
Target Names
PLPBP
Alternative Names
FLJ11861 antibody; Proline synthase co-transcribed bacterial homolog protein antibody; Proline synthetase co transcribed bacterial homolog antibody; Proline synthetase co transcribed homolog (bacterial) antibody; PROSC antibody; PROSC_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pyridoxal phosphate homeostasis protein (1-275AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
Gene References into Functions
  1. We therefore confirm PROSC as a novel gene for vitamin-B6-dependent epilepsy and delineate a non-specific plasma vitamin B6 profile under pyridoxine treatment. PMID: 28391250
  2. Exploiting the universality of the Synechococcus elongatus COG0325 (PiPY) functions, it has been used in site-directed mutagenesis studies to shed light on disease causation by epilepsy-associated mutations in the human COG0325 gene PROSC. PMID: 28914444
  3. studies suggest that PROSC is involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate, supplying this cofactor to apoenzymes while minimizing any toxic side reactions PMID: 27912044
Involvement in disease
Epilepsy, early-onset, vitamin B6-dependent (EPVB6D)
Protein Families
Pyridoxal phosphate-binding protein YggS/PROSC family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 9457

OMIM: 604436

KEGG: hsa:11212

STRING: 9606.ENSP00000333551

UniGene: Hs.304792

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