PRPF6 Antibody

Datasheet

Code	CSB-PA008476
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O94906

Target Names

PRPF6

Alternative Names

Androgen receptor N terminal domain transactivating protein 1 antibody; ANT 1 antibody; ANT1 antibody; C20orf14 antibody; hPrp6 antibody; p102 U5 small nuclear ribonucleoprotein particle binding protein antibody; pre-mRNA processing factor 6 antibody; Pre-mRNA-processing factor 6 antibody; PRP6 homolog antibody; PRP6 pre mRNA processing factor 6 homolog antibody; PRP6_HUMAN antibody; PRPF6 antibody; Putative mitochondrial outer membrane protein import receptor antibody; TOM antibody; U5 snRNP-associated 102 kDa protein antibody; U5-102 kDa protein antibody; U5-102K antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the C-terminal region of Human PRP6.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.

Gene References into Functions

an essential role for PRPF6 in cancer via splicing of distinct growth-related gene products. PMID: 24788092
Our results identify PRPF6 as the sixth gene involved in pre-mRNA splicing and dominant RP, corroborating the hypothesis that deficiencies in the spliceosome play an important role in the molecular pathology of this disease. PMID: 21549338
The authors provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes. PMID: 20118938
identification as a coactivator for the androgen receptor [p102 U5 small nuclear ribonucleoprotein particle-binding protein] PMID: 12039962
The interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), coupled with CD2BP2's absence from the tri-snRNP, suggests it might function in tri-snRNP assembly PMID: 15840814
C20orf14 may have a role in progression of lymphoma PMID: 18278469

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Involvement in disease

Retinitis pigmentosa 60 (RP60)

Subcellular Location

Nucleus, nucleoplasm. Nucleus speckle.

Tissue Specificity

Widely expressed.

Database Links

HGNC: 15860

OMIM: 613979

KEGG: hsa:24148

STRING: 9606.ENSP00000266079

UniGene: Hs.31334

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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