PRPF6 Antibody

Code CSB-PA018772XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PRPF6 Polyclonal antibody
Uniprot No.
Target Names
PRPF6
Alternative Names
Androgen receptor N terminal domain transactivating protein 1 antibody; ANT 1 antibody; ANT1 antibody; C20orf14 antibody; hPrp6 antibody; p102 U5 small nuclear ribonucleoprotein particle binding protein antibody; pre-mRNA processing factor 6 antibody; Pre-mRNA-processing factor 6 antibody; PRP6 homolog antibody; PRP6 pre mRNA processing factor 6 homolog antibody; PRP6_HUMAN antibody; PRPF6 antibody; Putative mitochondrial outer membrane protein import receptor antibody; TOM antibody; U5 snRNP-associated 102 kDa protein antibody; U5-102 kDa protein antibody; U5-102K antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) PRPF6 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Gene References into Functions
  1. an essential role for PRPF6 in cancer via splicing of distinct growth-related gene products. PMID: 24788092
  2. Our results identify PRPF6 as the sixth gene involved in pre-mRNA splicing and dominant RP, corroborating the hypothesis that deficiencies in the spliceosome play an important role in the molecular pathology of this disease. PMID: 21549338
  3. The authors provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes. PMID: 20118938
  4. identification as a coactivator for the androgen receptor [p102 U5 small nuclear ribonucleoprotein particle-binding protein] PMID: 12039962
  5. The interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), coupled with CD2BP2's absence from the tri-snRNP, suggests it might function in tri-snRNP assembly PMID: 15840814
  6. C20orf14 may have a role in progression of lymphoma PMID: 18278469

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Involvement in disease
Retinitis pigmentosa 60 (RP60)
Subcellular Location
Nucleus, nucleoplasm. Nucleus speckle.
Tissue Specificity
Widely expressed.
Database Links

HGNC: 15860

OMIM: 613979

KEGG: hsa:24148

STRING: 9606.ENSP00000266079

UniGene: Hs.31334

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