Product Details

Uniprot No.

Target Names

PSMA6

Alternative Names

27 kDa prosomal protein antibody; IOTA antibody; Macropain iota chain antibody; Macropain subunit iota antibody; MGC22756 antibody; MGC2333 antibody; MGC23846 antibody; Multicatalytic endopeptidase complex iota chain antibody; p27K antibody; PROS 27 antibody; PROS-27 antibody; PROS27 antibody; Prosomal P27K protein antibody; Proteasome (prosome macropain) subunit alpha type 6 antibody; Proteasome iota chain antibody; Proteasome subunit alpha type 6 antibody; Proteasome subunit alpha type-6 antibody; Proteasome subunit iota antibody; PSA6_HUMAN antibody; PSMA 6 antibody; PSMA6 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PSMA6

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene References into Functions

Results suggest that proteasome subunit alpha type 6 (PSMA6) serves as an attractive target with a high therapeutic index for lung cancer. PMID: 28165654
The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism -8 C/G associated with End-stage kidney disease and might be a protective factor for the disease. PMID: 27671905
These data indicate that hepatic expression of PSMA6, which is upregulated during viral hepatitis, likely depends on TLR3 activation and, that PSMA6 affects the expression of immunoregulatory ISG15, a proviral factor in the pathogenesis of hepatitis C virus infection. PMID: 26833585
Data indicate that proteasome subunit alpha 6 (PSMA6) direct contacts with proteasome subunit alpha 7 (PSMA7) tetradecamer. PMID: 26657688
Evidence of a sex-specific association of PSMA6 genetic variants with subtypes of juvenile idiopathic arthritis. PMID: 24875235
The data show that LMP2 and PSMA6 gene polymorphism is not a risk factor of ischemic stroke in Ukrainian population. PMID: 24809174
The PSMA6 variant rs1048990 appears to affect susceptibility to ischaemic stroke in both caucasian and african american populations. PMID: 22882272
The G allele of PSMA6-8C/G polymorphism is a risk factor associated with increased coronary artery disease susceptibility. [Meat-analysis] PMID: 23111455
Investigation suggests that -8 C/G variant of PSMA6 gene may be associated with T2DM and diabetes-related metabolic traits in Chinese Dongxiang and Han populations. PMID: 23026512
PSMA6 polymorphisms were not associated with phenotype of coronary atherosclerosis. PMID: 22310064
the G-allele of the PSMA6-8C>G polymorphism is a possible survival prognosticator in multiple myeloma PMID: 20408869
A total of 1330 cases and 2554 controls from Japanese and Korean populations for PSMA6 genotypes were investigated, and no evidence of the association was obtained in both Japanese and Korean populations. PMID: 19282875
PSMA6 rs_1048990 polymorphism may contribute to MI susceptibility in type 2 diabetes. PMID: 18358479
common SNP (minor allele frequency of 0.35) in the proteasome subunit alpha type 6 gene (PSMA6) conferring risk of myocardial infarction in the Japanese population PMID: 16845397
The reported genotype in PSMA6 appears not to contribute appreciably to myocardial infarction, but may contribute slightly to atherosclerosis in the present study population. PMID: 17384448
2 SNPs at positions -110 & -8 from translation start, in the promoter region & 5'UTR of PSMA6 were analyzed; genotype -8CG was more frequent in type 2 diabetes patients & haplotype C-110/G-8, compared to C-110/C-8 was associated with higher risk of NIDDM PMID: 17555133
The GG genotype for rs1048990 was less frequent in the UK population than in the Japanese population, and was associated with an odds ratio for mi of 1.09 per G allele in a co-dominant genetic model and 1.32 in a recessive genetic model. PMID: 18231128
Our results indicate that the PSMA6 variant rs1048990 is a risk factor of myocardial infarction in the Chinese population. PMID: 19272601
Obtained data suggest the LMP2 and PSMA6 gene polymorphisms significance as the risk factors of essential hypertension in adolescents. PMID: 19526842
Haplotypes in KIAA0391 and PSMA6 genes is a genetic link for myocardial infarction and coronary artery disease. PMID: 19624571