PSMB11 Antibody

1. We analysed thymic tissues from patients with trisomy 13 (n = 4), trisomy 18 (n = 14) and trisomy 21 (n = 13) for histological alterations, and for the expression of functionally important molecules such as beta5t, a thymoproteasome subunit, and cathepsins. PMID: 25556590
2. Histological diversity of type AB thymoma correlates with expression of a functional marker beta5t and abundance of TdT-positive lymphocytes. PMID: 24293611
3. provide the first evidence that the mechanism underlying BTZ resistance in these tumor cells is impaired binding of BTZ to the mutant beta5 subunit of the proteasome PMID: 21941364
4. Proteasome beta5t is expressed in most type B and in some type AB thymomas and is a marker useful in differentiating type B3 thymomas from thymic carcinomas when used in combination with other diagnostic markers. PMID: 21836487
5. results suggest a key role for beta5t in generating the MHC class I-restricted CD8(+) T cell repertoire during thymic selection PMID: 17540904
6. Human beta5t was expressed in approximately 80% of cortical thymic epithelial cells and some cortical dendritic cells PMID: 19289856

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HGNC: 31963

OMIM: 611137

KEGG: hsa:122706

STRING: 9606.ENSP00000386212

UniGene: Hs.508918