PSMB5 Antibody, Biotin conjugated

1. Our results suggest a potential role for PSMB5 as a biomarker and therapeutic target for Triple-negative breast cancer PMID: 28623645
2. Results identified PSMB5 Q62P mutation to underlie bortezomib resistance in Down-syndrome-associated acute myeloid leukemia cells. PMID: 28143565
3. Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3). PMID: 24627483
4. Nuclear MB1 expression was an independent predictor of worse survival in ovarian cancer. PMID: 19243813
5. critical role of PSMB5 in 20S proteasome-mediated protection against replicative senescence, pointing to a possible strategy for maintaining the integrity of culture-expanded bone marrow stromal cells by manipulating the expression of PSMB5 PMID: 24393841
6. The expression of proteasome beta5 decreases markedly in human atherosclerotic plaques. PMID: 22781773
7. Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10. PMID: 23018640
8. Letter/Case Reports: proteasome subunit beta5t is expressed in cervical ectopic thymoma. PMID: 22523338
9. PSMB5 overexpression is associated with Bortezomib resistance in myeloma. PMID: 21978467
10. No mutations or differences in PSMB5 mRNA expression were seen before bortezomib treatment in 3 multiple myeloma patients, but after treatment, 1 patient showed PSMB5 upregulation associated with bortezomib resistance. PMID: 21920470
11. CDK5 regulation of proteasome subunit PSMB5 was identified as a probable route to antineoplastic drug sensitization. PMID: 21289309
12. Expression of mutated PSMB5 was associated with the prevention of the accumulation of unfolded proteins PMID: 20555361
13. interaction of TAP1 and TAP2 and P-glycoprotein with proteasome subunits beta-5 and beta-5i suggest direct targeting of antigenic peptides to the ER via a TAP-proteasome association and a possible role for P-glycoprotein PMID: 15488952
14. Proteasome activity can be genetically "upregulated" in lens cells by overexpression of beta5 catalytic subunit. Resulting increase in proteasome activity leads to decrease in oxidized proteins and enhanced cell survival following oxidative stress. PMID: 17262013
15. G322A mutation of the PSMB5 gene is a novel mechanism for bortezomib resistance. PMID: 18502982
16. nonsynonymous coding single nucleotide polymorphismsin the proteasome beta 5 subunit gene did not show significant effects on proteasome activity, but SNPs did influence transcription PMID: 18519783
17. Overexpression of PSMB5 is an important mechanism for bortezomib resistance in Jurkat cell lines. PMID: 18562081
18. a novel mechanism of bortezomib resistance associated with the selective overexpression of a mutant PSMB5 protein PMID: 18565852
19. Mutations of the PSMB5 gene resulting in substitutions of Ala49 and Ala50 of PSMB5 protein can confer varying bortezomib resistance PMID: 19426847

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HGNC: 9542

OMIM: 600306

KEGG: hsa:5693

STRING: 9606.ENSP00000355325

UniGene: Hs.422990